Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type I receptor among chronic kidney disease patients in a Chinese population

Sui Lung Su, Kuo Cheng Lu, Yuh Feng Lin, Yu Juei Hsu, Pong Ying Lee, Hsin Yi Yang, Sen Yeong Kao

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is highly prevalent in Taiwan and an increasing number of patients are affected, with a high risk of progression to end-stage renal disease and huge medical expenses. It has been predicted that the presence of hypertension increases with decreasing renal function due to a decrease in sodium excretion and activation of the renin-angiotensin system (RAS). The aim of this study was to investigate the influence of genetic variants of the RAS gene on CKD.We performed a case control association study and genotyped 135 CKD patients and 270 healthy controls among Han Chinese in Taiwan. All subjects were genotyped for angiotensinogen (AGT-M235T, T174M, A-20C), angiotensin-I converting enzyme (ACE-A2350G) and angiotensin II type 1 receptor (AGTR1-A1166C, C573T, C-521T) polymorphisms of RAS genes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Significant associations were observed in ACE-A2350G and AGTR1-C573T polymorphism between CKD patients and controls. In regard to ACE-A2350G, compared with the AA genotype the GG genotype protected against CKD (adjusted odds ratio [OR] = 0.34; p = 0.01). In regard to AGTR1-C573T, the CT genotype was a risk for CKD compared with the CC genotype (adjusted OR = 1.82; p = 0.03). We conclude that ACE-A2350G and AGTR1-C573T polymorphisms are likely candidate determinants of CKD.

Original languageEnglish
Pages (from-to)148-154
Number of pages7
JournalJRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Volume13
Issue number1
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Peptidyl-Dipeptidase A
Chronic Renal Insufficiency
Angiotensin II
Population
Genes
Renin-Angiotensin System
Genotype
Taiwan
Odds Ratio
Angiotensinogen
Angiotensin Type 1 Receptor
angiotensin-producing serum enzyme II
Restriction Fragment Length Polymorphisms
Chronic Kidney Failure
Case-Control Studies
Sodium
Hypertension
Kidney
Polymerase Chain Reaction

Keywords

  • angiotensin II type 1 receptor (AGTR1)
  • angiotensin-I converting enzyme (ACE)
  • angiotensinogen (AGT)
  • Chronic kidney disease (CKD)
  • single nucleotide polymorphism (SNP)

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type I receptor among chronic kidney disease patients in a Chinese population. / Su, Sui Lung; Lu, Kuo Cheng; Lin, Yuh Feng; Hsu, Yu Juei; Lee, Pong Ying; Yang, Hsin Yi; Kao, Sen Yeong.

In: JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, Vol. 13, No. 1, 03.2012, p. 148-154.

Research output: Contribution to journalArticle

@article{a5bcf673a6b148fa865096b7c8de6b66,
title = "Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type I receptor among chronic kidney disease patients in a Chinese population",
abstract = "Chronic kidney disease (CKD) is highly prevalent in Taiwan and an increasing number of patients are affected, with a high risk of progression to end-stage renal disease and huge medical expenses. It has been predicted that the presence of hypertension increases with decreasing renal function due to a decrease in sodium excretion and activation of the renin-angiotensin system (RAS). The aim of this study was to investigate the influence of genetic variants of the RAS gene on CKD.We performed a case control association study and genotyped 135 CKD patients and 270 healthy controls among Han Chinese in Taiwan. All subjects were genotyped for angiotensinogen (AGT-M235T, T174M, A-20C), angiotensin-I converting enzyme (ACE-A2350G) and angiotensin II type 1 receptor (AGTR1-A1166C, C573T, C-521T) polymorphisms of RAS genes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Significant associations were observed in ACE-A2350G and AGTR1-C573T polymorphism between CKD patients and controls. In regard to ACE-A2350G, compared with the AA genotype the GG genotype protected against CKD (adjusted odds ratio [OR] = 0.34; p = 0.01). In regard to AGTR1-C573T, the CT genotype was a risk for CKD compared with the CC genotype (adjusted OR = 1.82; p = 0.03). We conclude that ACE-A2350G and AGTR1-C573T polymorphisms are likely candidate determinants of CKD.",
keywords = "angiotensin II type 1 receptor (AGTR1), angiotensin-I converting enzyme (ACE), angiotensinogen (AGT), Chronic kidney disease (CKD), single nucleotide polymorphism (SNP)",
author = "Su, {Sui Lung} and Lu, {Kuo Cheng} and Lin, {Yuh Feng} and Hsu, {Yu Juei} and Lee, {Pong Ying} and Yang, {Hsin Yi} and Kao, {Sen Yeong}",
year = "2012",
month = "3",
doi = "10.1177/1470320311430989",
language = "English",
volume = "13",
pages = "148--154",
journal = "JRAAS - Journal of the Renin-Angiotensin-Aldosterone System",
issn = "1470-3203",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Gene polymorphisms of angiotensin-converting enzyme and angiotensin II Type I receptor among chronic kidney disease patients in a Chinese population

AU - Su, Sui Lung

AU - Lu, Kuo Cheng

AU - Lin, Yuh Feng

AU - Hsu, Yu Juei

AU - Lee, Pong Ying

AU - Yang, Hsin Yi

AU - Kao, Sen Yeong

PY - 2012/3

Y1 - 2012/3

N2 - Chronic kidney disease (CKD) is highly prevalent in Taiwan and an increasing number of patients are affected, with a high risk of progression to end-stage renal disease and huge medical expenses. It has been predicted that the presence of hypertension increases with decreasing renal function due to a decrease in sodium excretion and activation of the renin-angiotensin system (RAS). The aim of this study was to investigate the influence of genetic variants of the RAS gene on CKD.We performed a case control association study and genotyped 135 CKD patients and 270 healthy controls among Han Chinese in Taiwan. All subjects were genotyped for angiotensinogen (AGT-M235T, T174M, A-20C), angiotensin-I converting enzyme (ACE-A2350G) and angiotensin II type 1 receptor (AGTR1-A1166C, C573T, C-521T) polymorphisms of RAS genes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Significant associations were observed in ACE-A2350G and AGTR1-C573T polymorphism between CKD patients and controls. In regard to ACE-A2350G, compared with the AA genotype the GG genotype protected against CKD (adjusted odds ratio [OR] = 0.34; p = 0.01). In regard to AGTR1-C573T, the CT genotype was a risk for CKD compared with the CC genotype (adjusted OR = 1.82; p = 0.03). We conclude that ACE-A2350G and AGTR1-C573T polymorphisms are likely candidate determinants of CKD.

AB - Chronic kidney disease (CKD) is highly prevalent in Taiwan and an increasing number of patients are affected, with a high risk of progression to end-stage renal disease and huge medical expenses. It has been predicted that the presence of hypertension increases with decreasing renal function due to a decrease in sodium excretion and activation of the renin-angiotensin system (RAS). The aim of this study was to investigate the influence of genetic variants of the RAS gene on CKD.We performed a case control association study and genotyped 135 CKD patients and 270 healthy controls among Han Chinese in Taiwan. All subjects were genotyped for angiotensinogen (AGT-M235T, T174M, A-20C), angiotensin-I converting enzyme (ACE-A2350G) and angiotensin II type 1 receptor (AGTR1-A1166C, C573T, C-521T) polymorphisms of RAS genes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Significant associations were observed in ACE-A2350G and AGTR1-C573T polymorphism between CKD patients and controls. In regard to ACE-A2350G, compared with the AA genotype the GG genotype protected against CKD (adjusted odds ratio [OR] = 0.34; p = 0.01). In regard to AGTR1-C573T, the CT genotype was a risk for CKD compared with the CC genotype (adjusted OR = 1.82; p = 0.03). We conclude that ACE-A2350G and AGTR1-C573T polymorphisms are likely candidate determinants of CKD.

KW - angiotensin II type 1 receptor (AGTR1)

KW - angiotensin-I converting enzyme (ACE)

KW - angiotensinogen (AGT)

KW - Chronic kidney disease (CKD)

KW - single nucleotide polymorphism (SNP)

UR - http://www.scopus.com/inward/record.url?scp=84859939183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859939183&partnerID=8YFLogxK

U2 - 10.1177/1470320311430989

DO - 10.1177/1470320311430989

M3 - Article

C2 - 22147663

AN - SCOPUS:84859939183

VL - 13

SP - 148

EP - 154

JO - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

JF - JRAAS - Journal of the Renin-Angiotensin-Aldosterone System

SN - 1470-3203

IS - 1

ER -