Gene-gene interactions in renin-angiotensin-aldosterone system contributes to end-stage renal disease susceptibility in a han chinese population

Sui Lung Su, Hsin Yi Yang, Chia Chao Wu, Herng Sheng Lee, Yuh Feng Lin, Chi An Hsu, Ching Huang Lai, Chin Lin, Sen Yeong Kao, Kuo Cheng Lu

Research output: Contribution to journalArticle

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Abstract

Objective. In this study, we investigated whether RAAS gene single nucleotide polymorphisms (SNPs) and their interactions were associated with end-stage renal stage (ESRD). Methodology and Results. This was a case-control study for 647 ESRD cases and 644 controls. AGT (M235T (rs699) and T174M (rs4762)), AGTR1 (A1166C (rs5186) and C573T (rs5182)), ACE (I/D (rs1799752) and G2350A (rs4343)), and CYP11B2 C-344T (rs1799998) were genotyped and compared between cases and controls to identify SNPs associated with ESRD susceptibility. Multifactor dimensionality reduction (MDR) was used to identify gene-gene interactions. Several RAAS genes were associated with ESRD: AGT M235T, ACE I/D, ACE G2350A, and CYP11B2 C-344T. By MDR analysis, a three-locus model (ACE ID/ACE G2350A/CYP11B2 C-344T) of gene-gene interaction was the best for predicting ESRD risk, and its maximum testing accuracy was 56.08% and maximum cross-validation consistency was 9/10. ESRD risk was higher with the simultaneous occurrence of ACE I/D DD-ACE G2350A AA. AGT, ACE, and CYP11B2 gene polymorphisms are associated with ESRD. Conclusions. The gene-gene interaction effects of ACE I/D, ACE G2350A, and CYP11B2 C-344T polymorphisms are more important than individual factors for ESRD development among Han Chinese.

Original languageEnglish
Article number169798
JournalScientific World Journal
Volume2014
DOIs
Publication statusPublished - 2014

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Disease Susceptibility
Angiotensins
Renin-Angiotensin System
Aldosterone
Renin
Chronic Kidney Failure
Cytochrome P-450 CYP11B2
Genes
gene
Population
Polymorphism
polymorphism
Multifactor Dimensionality Reduction
Single Nucleotide Polymorphism
Nucleotides
Case-Control Studies
Kidney
methodology
Testing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Gene-gene interactions in renin-angiotensin-aldosterone system contributes to end-stage renal disease susceptibility in a han chinese population. / Su, Sui Lung; Yang, Hsin Yi; Wu, Chia Chao; Lee, Herng Sheng; Lin, Yuh Feng; Hsu, Chi An; Lai, Ching Huang; Lin, Chin; Kao, Sen Yeong; Lu, Kuo Cheng.

In: Scientific World Journal, Vol. 2014, 169798, 2014.

Research output: Contribution to journalArticle

Su, Sui Lung ; Yang, Hsin Yi ; Wu, Chia Chao ; Lee, Herng Sheng ; Lin, Yuh Feng ; Hsu, Chi An ; Lai, Ching Huang ; Lin, Chin ; Kao, Sen Yeong ; Lu, Kuo Cheng. / Gene-gene interactions in renin-angiotensin-aldosterone system contributes to end-stage renal disease susceptibility in a han chinese population. In: Scientific World Journal. 2014 ; Vol. 2014.
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T1 - Gene-gene interactions in renin-angiotensin-aldosterone system contributes to end-stage renal disease susceptibility in a han chinese population

AU - Su, Sui Lung

AU - Yang, Hsin Yi

AU - Wu, Chia Chao

AU - Lee, Herng Sheng

AU - Lin, Yuh Feng

AU - Hsu, Chi An

AU - Lai, Ching Huang

AU - Lin, Chin

AU - Kao, Sen Yeong

AU - Lu, Kuo Cheng

PY - 2014

Y1 - 2014

N2 - Objective. In this study, we investigated whether RAAS gene single nucleotide polymorphisms (SNPs) and their interactions were associated with end-stage renal stage (ESRD). Methodology and Results. This was a case-control study for 647 ESRD cases and 644 controls. AGT (M235T (rs699) and T174M (rs4762)), AGTR1 (A1166C (rs5186) and C573T (rs5182)), ACE (I/D (rs1799752) and G2350A (rs4343)), and CYP11B2 C-344T (rs1799998) were genotyped and compared between cases and controls to identify SNPs associated with ESRD susceptibility. Multifactor dimensionality reduction (MDR) was used to identify gene-gene interactions. Several RAAS genes were associated with ESRD: AGT M235T, ACE I/D, ACE G2350A, and CYP11B2 C-344T. By MDR analysis, a three-locus model (ACE ID/ACE G2350A/CYP11B2 C-344T) of gene-gene interaction was the best for predicting ESRD risk, and its maximum testing accuracy was 56.08% and maximum cross-validation consistency was 9/10. ESRD risk was higher with the simultaneous occurrence of ACE I/D DD-ACE G2350A AA. AGT, ACE, and CYP11B2 gene polymorphisms are associated with ESRD. Conclusions. The gene-gene interaction effects of ACE I/D, ACE G2350A, and CYP11B2 C-344T polymorphisms are more important than individual factors for ESRD development among Han Chinese.

AB - Objective. In this study, we investigated whether RAAS gene single nucleotide polymorphisms (SNPs) and their interactions were associated with end-stage renal stage (ESRD). Methodology and Results. This was a case-control study for 647 ESRD cases and 644 controls. AGT (M235T (rs699) and T174M (rs4762)), AGTR1 (A1166C (rs5186) and C573T (rs5182)), ACE (I/D (rs1799752) and G2350A (rs4343)), and CYP11B2 C-344T (rs1799998) were genotyped and compared between cases and controls to identify SNPs associated with ESRD susceptibility. Multifactor dimensionality reduction (MDR) was used to identify gene-gene interactions. Several RAAS genes were associated with ESRD: AGT M235T, ACE I/D, ACE G2350A, and CYP11B2 C-344T. By MDR analysis, a three-locus model (ACE ID/ACE G2350A/CYP11B2 C-344T) of gene-gene interaction was the best for predicting ESRD risk, and its maximum testing accuracy was 56.08% and maximum cross-validation consistency was 9/10. ESRD risk was higher with the simultaneous occurrence of ACE I/D DD-ACE G2350A AA. AGT, ACE, and CYP11B2 gene polymorphisms are associated with ESRD. Conclusions. The gene-gene interaction effects of ACE I/D, ACE G2350A, and CYP11B2 C-344T polymorphisms are more important than individual factors for ESRD development among Han Chinese.

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