Gene, brains, and environment-genetic neuroimaging of depression

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Depression, conceptualized as major depressive disorder (MDD), is a complex psychiatric disorder with multiple behavioral changes and alterations in various brain regions. Biochemically, serotonin and others substances like GABA, glutamate, norepinephrin, adrenaline/noradrenaline play an essential role in the pathogenesis of MDD. The paper reviews recent human neuroimaging findings on how the genes underlying these biochemical substances modulate neural activity, behavior, and ultimately clinical symptoms. Current data provide solid evidence that genes related to serotonin impact emotion-related neural activity in the amygdala and the anterior cingulate cortex. By contrast, evidence is not as strong for genes related to biochemical substances other than serotonin and other regions of the brain. The review concludes with discussing future genetic, neural, and clinical challenges that point out the central role of gene. × environment and brain. × environment interactions as genetic and neural predispositions of depression.

Original languageEnglish
Pages (from-to)133-142
Number of pages10
JournalCurrent Opinion in Neurobiology
Volume23
Issue number1
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

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Neuroimaging
Depression
Serotonin
Major Depressive Disorder
Brain
Genes
Gyrus Cinguli
Genetic Predisposition to Disease
Amygdala
gamma-Aminobutyric Acid
Epinephrine
Psychiatry
Glutamic Acid
Norepinephrine
Emotions

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Gene, brains, and environment-genetic neuroimaging of depression. / Northoff, Georg.

In: Current Opinion in Neurobiology, Vol. 23, No. 1, 02.2013, p. 133-142.

Research output: Contribution to journalArticle

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