Gender differences and age-related white matter changes of the human brain: A diffusion tensor imaging study

Jung Lung Hsu, Alexander Leemans, Chyi Huey Bai, Cheng Hui Lee, Yuh Feng Tsai, Hou Chang Chiu, Wei Hung Chen

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

Cerebral white matter undergoes various changes with normal aging. This study investigated the association between age, gender, and the global and regional fractional anisotropy (FA) and mean diffusivity (MD) in 145 adults (30 to 80 years old) using diffusion tensor magnetic resonance imaging. We studied sixteen regions of interest in both hemispheres to search for regions that display age- and gender-related white matter changes and also performed a complementary voxel-based analysis without any hypothesis a priori. On a global scale, our results indicate that the full brain FA was negatively correlated with age. The regional analysis showed that the anterior corpus callosum, the bilateral anterior and posterior internal capsule, and the posterior periventricular regions had the most significant age-related FA decrease. On the other hand, the FA in the temporal and occipital regions was not correlated with age. However, in contrast to males, females overall had a significantly lower FA in the right deep temporal regions. More gender differences in precentral, cingulate, and anterior temporal white matter areas were also found, suggesting that microstructural white matter organization in these regions may have a sexual dimorphism. Such differences were mainly due to the increase in diffusion perpendicular to fiber tracts.

Original languageEnglish
Pages (from-to)566-577
Number of pages12
JournalNeuroImage
Volume39
Issue number2
DOIs
Publication statusPublished - Jan 15 2008
Externally publishedYes

Fingerprint

Diffusion Tensor Imaging
Anisotropy
Brain
Temporal Lobe
Internal Capsule
Occipital Lobe
Diffusion Magnetic Resonance Imaging
Corpus Callosum
Gyrus Cinguli
Sex Characteristics
White Matter

Keywords

  • Aging
  • Diffusion tensor imaging
  • Fractional anisotropy
  • Gender
  • Voxel-based morphometry
  • White matter

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Gender differences and age-related white matter changes of the human brain : A diffusion tensor imaging study. / Hsu, Jung Lung; Leemans, Alexander; Bai, Chyi Huey; Lee, Cheng Hui; Tsai, Yuh Feng; Chiu, Hou Chang; Chen, Wei Hung.

In: NeuroImage, Vol. 39, No. 2, 15.01.2008, p. 566-577.

Research output: Contribution to journalArticle

Hsu, Jung Lung ; Leemans, Alexander ; Bai, Chyi Huey ; Lee, Cheng Hui ; Tsai, Yuh Feng ; Chiu, Hou Chang ; Chen, Wei Hung. / Gender differences and age-related white matter changes of the human brain : A diffusion tensor imaging study. In: NeuroImage. 2008 ; Vol. 39, No. 2. pp. 566-577.
@article{60eacbc76fcf44368a21e6cf5cbc9678,
title = "Gender differences and age-related white matter changes of the human brain: A diffusion tensor imaging study",
abstract = "Cerebral white matter undergoes various changes with normal aging. This study investigated the association between age, gender, and the global and regional fractional anisotropy (FA) and mean diffusivity (MD) in 145 adults (30 to 80 years old) using diffusion tensor magnetic resonance imaging. We studied sixteen regions of interest in both hemispheres to search for regions that display age- and gender-related white matter changes and also performed a complementary voxel-based analysis without any hypothesis a priori. On a global scale, our results indicate that the full brain FA was negatively correlated with age. The regional analysis showed that the anterior corpus callosum, the bilateral anterior and posterior internal capsule, and the posterior periventricular regions had the most significant age-related FA decrease. On the other hand, the FA in the temporal and occipital regions was not correlated with age. However, in contrast to males, females overall had a significantly lower FA in the right deep temporal regions. More gender differences in precentral, cingulate, and anterior temporal white matter areas were also found, suggesting that microstructural white matter organization in these regions may have a sexual dimorphism. Such differences were mainly due to the increase in diffusion perpendicular to fiber tracts.",
keywords = "Aging, Diffusion tensor imaging, Fractional anisotropy, Gender, Voxel-based morphometry, White matter",
author = "Hsu, {Jung Lung} and Alexander Leemans and Bai, {Chyi Huey} and Lee, {Cheng Hui} and Tsai, {Yuh Feng} and Chiu, {Hou Chang} and Chen, {Wei Hung}",
year = "2008",
month = "1",
day = "15",
doi = "10.1016/j.neuroimage.2007.09.017",
language = "English",
volume = "39",
pages = "566--577",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Gender differences and age-related white matter changes of the human brain

T2 - A diffusion tensor imaging study

AU - Hsu, Jung Lung

AU - Leemans, Alexander

AU - Bai, Chyi Huey

AU - Lee, Cheng Hui

AU - Tsai, Yuh Feng

AU - Chiu, Hou Chang

AU - Chen, Wei Hung

PY - 2008/1/15

Y1 - 2008/1/15

N2 - Cerebral white matter undergoes various changes with normal aging. This study investigated the association between age, gender, and the global and regional fractional anisotropy (FA) and mean diffusivity (MD) in 145 adults (30 to 80 years old) using diffusion tensor magnetic resonance imaging. We studied sixteen regions of interest in both hemispheres to search for regions that display age- and gender-related white matter changes and also performed a complementary voxel-based analysis without any hypothesis a priori. On a global scale, our results indicate that the full brain FA was negatively correlated with age. The regional analysis showed that the anterior corpus callosum, the bilateral anterior and posterior internal capsule, and the posterior periventricular regions had the most significant age-related FA decrease. On the other hand, the FA in the temporal and occipital regions was not correlated with age. However, in contrast to males, females overall had a significantly lower FA in the right deep temporal regions. More gender differences in precentral, cingulate, and anterior temporal white matter areas were also found, suggesting that microstructural white matter organization in these regions may have a sexual dimorphism. Such differences were mainly due to the increase in diffusion perpendicular to fiber tracts.

AB - Cerebral white matter undergoes various changes with normal aging. This study investigated the association between age, gender, and the global and regional fractional anisotropy (FA) and mean diffusivity (MD) in 145 adults (30 to 80 years old) using diffusion tensor magnetic resonance imaging. We studied sixteen regions of interest in both hemispheres to search for regions that display age- and gender-related white matter changes and also performed a complementary voxel-based analysis without any hypothesis a priori. On a global scale, our results indicate that the full brain FA was negatively correlated with age. The regional analysis showed that the anterior corpus callosum, the bilateral anterior and posterior internal capsule, and the posterior periventricular regions had the most significant age-related FA decrease. On the other hand, the FA in the temporal and occipital regions was not correlated with age. However, in contrast to males, females overall had a significantly lower FA in the right deep temporal regions. More gender differences in precentral, cingulate, and anterior temporal white matter areas were also found, suggesting that microstructural white matter organization in these regions may have a sexual dimorphism. Such differences were mainly due to the increase in diffusion perpendicular to fiber tracts.

KW - Aging

KW - Diffusion tensor imaging

KW - Fractional anisotropy

KW - Gender

KW - Voxel-based morphometry

KW - White matter

UR - http://www.scopus.com/inward/record.url?scp=36148964463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36148964463&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2007.09.017

DO - 10.1016/j.neuroimage.2007.09.017

M3 - Article

C2 - 17951075

AN - SCOPUS:36148964463

VL - 39

SP - 566

EP - 577

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 2

ER -