Gender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma

Chih Jung Chen, Wen Wei Sung, Yueh Min Lin, Mu Kuan Chen, Ching Hsiao Lee, Huei Lee, Kun Tu Yeh, Jiunn Liang Ko

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Interleukin 6 (IL6) plays an important role in immunoregulation and tumorigenesis in human cancers. Oral squamous cell carcinoma (OSCC) is a malignant tumor of the oral cavity with a male predominant tendency and a poor clinical prognosis. Due to the relatively few cases in females, the gender difference of prognostic markers for OSCC is seldom discussed. Methods: In this study, we used immunohistochemical staining methods to investigate the associations between IL6 expression and the clinicopathological characteristics of OSCC. In addition, we collected 74 female and 263 male OSCC patients for evaluation. Results: High IL6 expression in tumor cells was significantly associated OSCC patient characteristics including female gender (P<0.001), high lymph node metastatic rate (P = 0.007), and poor tumor differentiation (P = 0.008). Tumor-expressed IL6 had prognostic role in male OSCC patients as defined by the log-rank test (P = 0.014), but not in female patients (P = 0.959). In male OSCC patients, high IL6 expression in tumor cells was associated with poor prognosis (P = 0.025) and a 1.454-fold higher death risk, as determined by Cox regression. Conclusions: High IL6 expression in tumor cells was therefore significantly associated with aggressive clinical manifestations and might be an independent survival predictor, particularly in male OSCC patients. © 2012 Chen et al.

Original languageEnglish
Article numbere50104
JournalPLoS One
Volume7
Issue number11
DOIs
Publication statusPublished - Nov 21 2012
Externally publishedYes

Fingerprint

squamous cell carcinoma
interleukin-6
gender differences
Squamous Cell Carcinoma
mouth
Interleukin-6
Tumors
Neoplasms
Cells
neoplasms
prognosis
Epithelial Cells
immunomodulation
Mouth
carcinogenesis
Carcinogenesis
lymph nodes
Lymph Nodes
Staining and Labeling
death

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Chen, C. J., Sung, W. W., Lin, Y. M., Chen, M. K., Lee, C. H., Lee, H., ... Ko, J. L. (2012). Gender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma. PLoS One, 7(11), [e50104]. https://doi.org/10.1371/journal.pone.0050104

Gender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma. / Chen, Chih Jung; Sung, Wen Wei; Lin, Yueh Min; Chen, Mu Kuan; Lee, Ching Hsiao; Lee, Huei; Yeh, Kun Tu; Ko, Jiunn Liang.

In: PLoS One, Vol. 7, No. 11, e50104, 21.11.2012.

Research output: Contribution to journalArticle

Chen, CJ, Sung, WW, Lin, YM, Chen, MK, Lee, CH, Lee, H, Yeh, KT & Ko, JL 2012, 'Gender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma', PLoS One, vol. 7, no. 11, e50104. https://doi.org/10.1371/journal.pone.0050104
Chen, Chih Jung ; Sung, Wen Wei ; Lin, Yueh Min ; Chen, Mu Kuan ; Lee, Ching Hsiao ; Lee, Huei ; Yeh, Kun Tu ; Ko, Jiunn Liang. / Gender Difference in the Prognostic Role of Interleukin 6 in Oral Squamous Cell Carcinoma. In: PLoS One. 2012 ; Vol. 7, No. 11.
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