Gender difference in clinical and genetic characteristics of Brugada syndrome: SADS-TW BrS registry

SADS-TW BrS Registry

Research output: Contribution to journalArticle

Abstract

Background: Brugada syndrome (BrS) is a heritable sudden cardiac death (SCD) disease with male predominance. Information on gender difference of BrS remains scarce. Aim: To investigate the gender difference of BrS in Han Chinese. Design: We consecutively enrolled 169 BrS patients (153 males and 16 females) from Han Chinese in Taiwan from 1998 to 2017. Methods: Clinical characteristics, electrocardiographic parameters and SCN5A mutation status were compared between genders. Results: The percentage of family history of SCD in females was slightly higher (31.3% vs. 15%, P ¼ 0.15). Females exhibited longer QTc (457.8 6 33.0 vs. 429.5 6 42.1 ms, P < 0.01). Regarding cumulative event occurrence by age, Mantel-Cox test showed females had earlier age of onset of first cardiac events (SCD or syncope) than males (P ¼ 0.049), which was mainly attributed to syncope (P < 0.01). Males with SCD exhibited longer QRS duration (114.2 6 26.8 vs. 104.8 6 15.3 ms, P ¼ 0.02) and QTc (442.5 6 57.4 vs. 422.9 6 28.8 ms, P ¼ 0.02). Males with syncope exhibited longer PR interval (181.2 6 33.7 vs. 165.7 6 27.1 ms, P ¼ 0.01), whereas females with SCD or syncope had a trend towards slower heart rates (69.1 6 9.6 vs. 82.2 6 16.3 bpm, P ¼ 0.10) than female with no or mild symptoms. There was no difference in the percentage of SCN5A mutation between genders. Conclusion: Gender difference is present in BrS. Females have longer QTc and suffer from syncope earlier than males. Risk of SCD in males is associated with boarder QRS complex and longer QTc, whereas risk of syncope is associated with longer PR interval in males and slower heart rate in females.

Original languageEnglish
Pages (from-to)343-350
Number of pages8
JournalQJM
Volume112
Issue number5
DOIs
Publication statusPublished - May 1 2019

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Brugada Syndrome
Registries
Sudden Cardiac Death
Syncope
Heart Rate
Mutation
Taiwan
Age of Onset
Heart Diseases

ASJC Scopus subject areas

  • Medicine(all)

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Gender difference in clinical and genetic characteristics of Brugada syndrome : SADS-TW BrS registry. / SADS-TW BrS Registry.

In: QJM, Vol. 112, No. 5, 01.05.2019, p. 343-350.

Research output: Contribution to journalArticle

@article{4f12ef0ee412420b8896131e06da2101,
title = "Gender difference in clinical and genetic characteristics of Brugada syndrome: SADS-TW BrS registry",
abstract = "Background: Brugada syndrome (BrS) is a heritable sudden cardiac death (SCD) disease with male predominance. Information on gender difference of BrS remains scarce. Aim: To investigate the gender difference of BrS in Han Chinese. Design: We consecutively enrolled 169 BrS patients (153 males and 16 females) from Han Chinese in Taiwan from 1998 to 2017. Methods: Clinical characteristics, electrocardiographic parameters and SCN5A mutation status were compared between genders. Results: The percentage of family history of SCD in females was slightly higher (31.3{\%} vs. 15{\%}, P ¼ 0.15). Females exhibited longer QTc (457.8 6 33.0 vs. 429.5 6 42.1 ms, P < 0.01). Regarding cumulative event occurrence by age, Mantel-Cox test showed females had earlier age of onset of first cardiac events (SCD or syncope) than males (P ¼ 0.049), which was mainly attributed to syncope (P < 0.01). Males with SCD exhibited longer QRS duration (114.2 6 26.8 vs. 104.8 6 15.3 ms, P ¼ 0.02) and QTc (442.5 6 57.4 vs. 422.9 6 28.8 ms, P ¼ 0.02). Males with syncope exhibited longer PR interval (181.2 6 33.7 vs. 165.7 6 27.1 ms, P ¼ 0.01), whereas females with SCD or syncope had a trend towards slower heart rates (69.1 6 9.6 vs. 82.2 6 16.3 bpm, P ¼ 0.10) than female with no or mild symptoms. There was no difference in the percentage of SCN5A mutation between genders. Conclusion: Gender difference is present in BrS. Females have longer QTc and suffer from syncope earlier than males. Risk of SCD in males is associated with boarder QRS complex and longer QTc, whereas risk of syncope is associated with longer PR interval in males and slower heart rate in females.",
author = "{SADS-TW BrS Registry} and Chen, {C. Y.J.} and Juang, {J. M.J.} and Lin, {L. Y.} and Liu, {Y. B.} and Ho, {L. T.} and Yu, {C. C.} and Huang, {H. C.} and Lin, {T. T.} and Liao, {M. C.} and Chen, {J. J.} and Hwang, {J. J.} and Chen, {W. J.} and Yeh, {S. F.S.} and Yang, {D. H.} and Chiang, {F. T.} and Lin, {J. L.} and Lai, {L. P.} and M. Horie and Wu, {Mei Hwan} and Wu, {Tsu Juey} and Chen, {Shih Ann} and Wang, {Chun Chieh} and Chang, {Kuan Cheng} and Feng, {An Ning} and Lin, {Yenn Jiang} and Ueng, {Kwo Chang} and Tsao, {Hsuan Ming} and Huang, {Jin Long} and Tsai, {Wen Chin} and Tsai, {Chin Feng} and Chang, {Shih Lin} and Lo, {Li Wei} and Hu, {Yu Feng} and Chung, {Fa Po} and Chang, {Chien Jung} and Lo, {Huey Ming} and Chiang, {Meng Cheng} and Hsia, {Chih Ping} and Liu, {Jen Fu} and Chiu, {Shuenn Nan} and Lin, {Ming Tai} and Chua, {Su Kiat} and Hsieh, {Yu Cheng} and Li, {Cheng Hung} and Liao, {Ying Chieh} and Lin, {Heng Hsu} and Liu, {Zhi Zhong} and Ye, {Guan Hong} and Chiu, {Wei Ru} and Chang, {Jian Rong}",
year = "2019",
month = "5",
day = "1",
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language = "English",
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pages = "343--350",
journal = "QJM - Monthly Journal of the Association of Physicians",
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TY - JOUR

T1 - Gender difference in clinical and genetic characteristics of Brugada syndrome

T2 - SADS-TW BrS registry

AU - SADS-TW BrS Registry

AU - Chen, C. Y.J.

AU - Juang, J. M.J.

AU - Lin, L. Y.

AU - Liu, Y. B.

AU - Ho, L. T.

AU - Yu, C. C.

AU - Huang, H. C.

AU - Lin, T. T.

AU - Liao, M. C.

AU - Chen, J. J.

AU - Hwang, J. J.

AU - Chen, W. J.

AU - Yeh, S. F.S.

AU - Yang, D. H.

AU - Chiang, F. T.

AU - Lin, J. L.

AU - Lai, L. P.

AU - Horie, M.

AU - Wu, Mei Hwan

AU - Wu, Tsu Juey

AU - Chen, Shih Ann

AU - Wang, Chun Chieh

AU - Chang, Kuan Cheng

AU - Feng, An Ning

AU - Lin, Yenn Jiang

AU - Ueng, Kwo Chang

AU - Tsao, Hsuan Ming

AU - Huang, Jin Long

AU - Tsai, Wen Chin

AU - Tsai, Chin Feng

AU - Chang, Shih Lin

AU - Lo, Li Wei

AU - Hu, Yu Feng

AU - Chung, Fa Po

AU - Chang, Chien Jung

AU - Lo, Huey Ming

AU - Chiang, Meng Cheng

AU - Hsia, Chih Ping

AU - Liu, Jen Fu

AU - Chiu, Shuenn Nan

AU - Lin, Ming Tai

AU - Chua, Su Kiat

AU - Hsieh, Yu Cheng

AU - Li, Cheng Hung

AU - Liao, Ying Chieh

AU - Lin, Heng Hsu

AU - Liu, Zhi Zhong

AU - Ye, Guan Hong

AU - Chiu, Wei Ru

AU - Chang, Jian Rong

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Background: Brugada syndrome (BrS) is a heritable sudden cardiac death (SCD) disease with male predominance. Information on gender difference of BrS remains scarce. Aim: To investigate the gender difference of BrS in Han Chinese. Design: We consecutively enrolled 169 BrS patients (153 males and 16 females) from Han Chinese in Taiwan from 1998 to 2017. Methods: Clinical characteristics, electrocardiographic parameters and SCN5A mutation status were compared between genders. Results: The percentage of family history of SCD in females was slightly higher (31.3% vs. 15%, P ¼ 0.15). Females exhibited longer QTc (457.8 6 33.0 vs. 429.5 6 42.1 ms, P < 0.01). Regarding cumulative event occurrence by age, Mantel-Cox test showed females had earlier age of onset of first cardiac events (SCD or syncope) than males (P ¼ 0.049), which was mainly attributed to syncope (P < 0.01). Males with SCD exhibited longer QRS duration (114.2 6 26.8 vs. 104.8 6 15.3 ms, P ¼ 0.02) and QTc (442.5 6 57.4 vs. 422.9 6 28.8 ms, P ¼ 0.02). Males with syncope exhibited longer PR interval (181.2 6 33.7 vs. 165.7 6 27.1 ms, P ¼ 0.01), whereas females with SCD or syncope had a trend towards slower heart rates (69.1 6 9.6 vs. 82.2 6 16.3 bpm, P ¼ 0.10) than female with no or mild symptoms. There was no difference in the percentage of SCN5A mutation between genders. Conclusion: Gender difference is present in BrS. Females have longer QTc and suffer from syncope earlier than males. Risk of SCD in males is associated with boarder QRS complex and longer QTc, whereas risk of syncope is associated with longer PR interval in males and slower heart rate in females.

AB - Background: Brugada syndrome (BrS) is a heritable sudden cardiac death (SCD) disease with male predominance. Information on gender difference of BrS remains scarce. Aim: To investigate the gender difference of BrS in Han Chinese. Design: We consecutively enrolled 169 BrS patients (153 males and 16 females) from Han Chinese in Taiwan from 1998 to 2017. Methods: Clinical characteristics, electrocardiographic parameters and SCN5A mutation status were compared between genders. Results: The percentage of family history of SCD in females was slightly higher (31.3% vs. 15%, P ¼ 0.15). Females exhibited longer QTc (457.8 6 33.0 vs. 429.5 6 42.1 ms, P < 0.01). Regarding cumulative event occurrence by age, Mantel-Cox test showed females had earlier age of onset of first cardiac events (SCD or syncope) than males (P ¼ 0.049), which was mainly attributed to syncope (P < 0.01). Males with SCD exhibited longer QRS duration (114.2 6 26.8 vs. 104.8 6 15.3 ms, P ¼ 0.02) and QTc (442.5 6 57.4 vs. 422.9 6 28.8 ms, P ¼ 0.02). Males with syncope exhibited longer PR interval (181.2 6 33.7 vs. 165.7 6 27.1 ms, P ¼ 0.01), whereas females with SCD or syncope had a trend towards slower heart rates (69.1 6 9.6 vs. 82.2 6 16.3 bpm, P ¼ 0.10) than female with no or mild symptoms. There was no difference in the percentage of SCN5A mutation between genders. Conclusion: Gender difference is present in BrS. Females have longer QTc and suffer from syncope earlier than males. Risk of SCD in males is associated with boarder QRS complex and longer QTc, whereas risk of syncope is associated with longer PR interval in males and slower heart rate in females.

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U2 - 10.1093/qjmed/hcz028

DO - 10.1093/qjmed/hcz028

M3 - Article

C2 - 30690642

AN - SCOPUS:85065670068

VL - 112

SP - 343

EP - 350

JO - QJM - Monthly Journal of the Association of Physicians

JF - QJM - Monthly Journal of the Association of Physicians

SN - 1460-2725

IS - 5

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