Gender-based personalized pharmacotherapy: a systematic review

Md Mohaimenul Islam, Usman Iqbal, Bruno Andreas Walther, Phung Anh Nguyen, Yu Chuan (Jack) Li, Navneet Kumar Dubey, Tahmina Nasrin Poly, Jakir Hossain Bhuiyan Masud, Suleman Atique, Shabbir Syed-Abdul

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Purpose: In general, male and female are prescribed the same amount of dosage even if most of the cases female required less dosage than male. Physicians are often facing problem on appropriate drug dosing, efficient treatment, and drug safety for a female in general. To identify and synthesize evidence about the effectiveness of gender-based therapy; provide the information to patients, providers, and health system intervention to ensure safety treatment; and minimize adverse effects. Methods: We performed a systematic review to evaluate the effect of gender difference on pharmacotherapy. Published articles from January 1990 to December 2015 were identified using specific term in MEDLINE (PubMed), EMBASE, and the Cochrane library according to search strategies that strengthen the reporting of observational and clinical studies. Results: Twenty-six studies fulfilled the inclusion criteria for this systematic review, yielding a total of 6309 subjects. We observed that female generally has a lower the gastric emptying time, gastric PH, lean body mass, and higher plasma volume, BMI, body fat, as well as reduce hepatic clearance, difference in activity of Cytochrome P450 enzyme, and metabolize drugs at different rate compared with male. Other significant factors such as conjugation, protein binding, absorption, and the renal elimination could not be ignored. However, these differences can lead to adverse effects in female especially for the pregnant, post-menopausal, and elderly women. Conclusion: This systematic review provides an evidence for the effectiveness of dosage difference to ensure safety and efficient treatment. Future studies on the current topic are, therefore, recommended to reduce the adverse effect of therapy.

Original languageEnglish
Pages (from-to)1305-1317
Number of pages13
JournalArchives of Gynecology and Obstetrics
Volume295
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Drug Therapy
Safety
Cytochrome P-450 Enzyme System
Pharmaceutical Preparations
Therapeutics
Plasma Volume
Gastric Emptying
PubMed
Protein Binding
MEDLINE
Libraries
Observational Studies
Adipose Tissue
Stomach
Physicians
Liver
Health

Keywords

  • Adverse effect
  • Drug interaction
  • Gender-based
  • Pharmacokinetics
  • Pharmacotherapy

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

Cite this

Gender-based personalized pharmacotherapy : a systematic review. / Islam, Md Mohaimenul; Iqbal, Usman; Walther, Bruno Andreas; Nguyen, Phung Anh; Li, Yu Chuan (Jack); Dubey, Navneet Kumar; Poly, Tahmina Nasrin; Masud, Jakir Hossain Bhuiyan; Atique, Suleman; Syed-Abdul, Shabbir.

In: Archives of Gynecology and Obstetrics, Vol. 295, No. 6, 01.06.2017, p. 1305-1317.

Research output: Contribution to journalReview article

Islam, MM, Iqbal, U, Walther, BA, Nguyen, PA, Li, YCJ, Dubey, NK, Poly, TN, Masud, JHB, Atique, S & Syed-Abdul, S 2017, 'Gender-based personalized pharmacotherapy: a systematic review', Archives of Gynecology and Obstetrics, vol. 295, no. 6, pp. 1305-1317. https://doi.org/10.1007/s00404-017-4363-3
Islam, Md Mohaimenul ; Iqbal, Usman ; Walther, Bruno Andreas ; Nguyen, Phung Anh ; Li, Yu Chuan (Jack) ; Dubey, Navneet Kumar ; Poly, Tahmina Nasrin ; Masud, Jakir Hossain Bhuiyan ; Atique, Suleman ; Syed-Abdul, Shabbir. / Gender-based personalized pharmacotherapy : a systematic review. In: Archives of Gynecology and Obstetrics. 2017 ; Vol. 295, No. 6. pp. 1305-1317.
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AU - Dubey, Navneet Kumar

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