Gender and age differences in short- and long-term outcomes following primary percutaneous coronary intervention for ST-elevation myocardial infarction

Su Kiat Chua, Kou Gi Shyu, Huei Fong Hung, Jun Jack Cheng, Huey Ming Lo, Shih Chi Liu, Lung Ching Chen, Ng Zuan Chiu, Che Ming Chang, Shen Chang Lin, Jer Young Liou, Shih Huang Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Studies have reported that women with ST elevationmyocardial infarction (STEMI) have worse shortand long-term outcomes than men. It has not yet been confirmed whether these differences reflect differences in age between men and women. Methods: We retrospectively enrolled 1035 consecutive STEMI patients treated with primary percutaneous coronary intervention (PCI). Baseline clinical characteristics, coronary anatomy, and outcome were compared between young (<65 years old) and older patients (≥ 65 years old) of both sexes. Results: Younger women presented with a lower incidence of typical angina (83% vs. 93%, p = 0.03), single-vessel disease (21% vs. 35%, p = 0.03), and total occlusion of infarct-related artery (65% vs. 83%, p = 0.001) than younger men, with no gender difference noted in the older group. Younger women in the study had a higher incidence of reinfarction, heart failure requiring admission, or mortality (23% vs. 6%, p <0.001) during follow-up, compared with younger men, with no gender difference in the older group. Using the Kaplan-Meier analysis, younger women had lower rates of event-free survival (p <0.001 by log-rank test) than younger men, with no gender difference in the older group. In multivariate analysis, age could predict long-term outcome in men (Hazard ratio 4.43, 95% confidence interval: 2.89-6.78, p <0.001) but not in women. Conclusions: In STEMI patients receiving primary PCI, sex-related long-term outcome differences were agedependent, with younger women likely to have a worse long-term outcome when compared with younger men.

Original languageEnglish
Pages (from-to)274-283
Number of pages10
JournalActa Cardiologica Sinica
Volume30
Issue number4
Publication statusPublished - Jul 1 2014

Keywords

  • Coronary heart disease
  • Gender
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Gender and age differences in short- and long-term outcomes following primary percutaneous coronary intervention for ST-elevation myocardial infarction'. Together they form a unique fingerprint.

  • Cite this

    Chua, S. K., Shyu, K. G., Hung, H. F., Cheng, J. J., Lo, H. M., Liu, S. C., Chen, L. C., Chiu, N. Z., Chang, C. M., Lin, S. C., Liou, J. Y., & Lee, S. H. (2014). Gender and age differences in short- and long-term outcomes following primary percutaneous coronary intervention for ST-elevation myocardial infarction. Acta Cardiologica Sinica, 30(4), 274-283.