Gelatin Methacrylate Hydrogel for Tissue Engineering Applications—A Review on Material Modifications

Sasinan Bupphathong, Carlos Quiroz, Wei Huang, Pei Feng Chung, Hsuan Ya Tao, Chih Hsin Lin

Research output: Contribution to journalReview articlepeer-review

Abstract

To recreate or substitute tissue in vivo is a complicated endeavor that requires biomaterials that can mimic the natural tissue environment. Gelatin methacrylate (GelMA) is created through covalent bonding of naturally derived polymer gelatin and methacrylic groups. Due to its biocompatibility, GelMA receives a lot of attention in the tissue engineering research field. Additionally, GelMA has versatile physical properties that allow a broad range of modifications to enhance the interaction between the material and the cells. In this review, we look at recent modifications of GelMA with naturally derived polymers, nanomaterials, and growth factors, focusing on recent developments for vascular tissue engineering and wound healing applications. Compared to polymers and nanoparticles, the modifications that embed growth factors show better mechanical properties and better cell migration, stimulating vascular development and a structure comparable to the natural-extracellular matrix.

Original languageEnglish
Article number171
JournalPharmaceuticals
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Biomaterials
  • GelMA
  • Hydrogel
  • Material modifications
  • Tissue engineering
  • Vascularization

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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