Abstract

Ping-Wei San (PWS), a Chinese medical decoction, was used to improve digestive absorption. This study was aimed to determine whether treatment with PWS reduce gastric ulceration induced by indomethacin and influencing its anti-inflammatory effect. PWS was extracted with boiling water and the decoction was freeze-dried into powder (H-PWS). The amounts of glycyrrhizin and hesperidin in H-PWS were analyzed by a HPLC method to be 38 and 19 mg/g, respectively. Co-administration of H-PWS resulted in a dose-dependent inhibition of indomethacin-induced gastric mucosal cell death. H-PWS (200 mg/kg) also alleviated the indomethacin-induced gastric ulcer in male Wistar rats in vivo. The inhibition effects of NO and PGE 2 production were enhanced by indomethancin co-treatment with H-PWS from LPS-stimulated RAW 264.7 cells. H-PWS (200 mg/kg) also augmented the anti-inflammatory effect of indomethacin in 1% carrageen-induced paw edema. Moreover, H-PWS co-treatment with indomethacin produced a lower PGE 2 level in serum than only indomethacin. Based on the results, co-treatment with H-PWS reduced the occurrence of indomethacin-induced gastric ulcers without affecting the anti-inflammatory effect of indomethacin. Therefore, we suggested that H-PWS can be developed as an anti-ulcer drug and H-PWS could be taken with indomethacin to decrease ulceration.

Original languageEnglish
JournalJournal of Food and Drug Analysis
Volume19
Issue number4
Publication statusPublished - Dec 2011

Fingerprint

stomach ulcers
indomethacin
Stomach Ulcer
Indomethacin
anti-inflammatory activity
Anti-Inflammatory Agents
stomach
Prostaglandins E
glycyrrhizin
hesperidin
ping wei san
Chondrus
Stomach
intestinal absorption
Anti-Ulcer Agents
Hesperidin
boiling
Glycyrrhizic Acid
edema
cell death

Keywords

  • Anti-inflammation
  • Gastric ulcer
  • Indomethacin
  • Ping-Wei San

ASJC Scopus subject areas

  • Food Science
  • Pharmacology

Cite this

Gastroprotective effects of Ping-Wei San on indomethacin-induced gastric ulcer. / Tiong, Cheng; Liang, Wen Li; Liu, Hsiang Yin; Wang, Kun Teng; Chang, Chun Chao; Wang, Ching Chiung.

In: Journal of Food and Drug Analysis, Vol. 19, No. 4, 12.2011.

Research output: Contribution to journalArticle

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abstract = "Ping-Wei San (PWS), a Chinese medical decoction, was used to improve digestive absorption. This study was aimed to determine whether treatment with PWS reduce gastric ulceration induced by indomethacin and influencing its anti-inflammatory effect. PWS was extracted with boiling water and the decoction was freeze-dried into powder (H-PWS). The amounts of glycyrrhizin and hesperidin in H-PWS were analyzed by a HPLC method to be 38 and 19 mg/g, respectively. Co-administration of H-PWS resulted in a dose-dependent inhibition of indomethacin-induced gastric mucosal cell death. H-PWS (200 mg/kg) also alleviated the indomethacin-induced gastric ulcer in male Wistar rats in vivo. The inhibition effects of NO and PGE 2 production were enhanced by indomethancin co-treatment with H-PWS from LPS-stimulated RAW 264.7 cells. H-PWS (200 mg/kg) also augmented the anti-inflammatory effect of indomethacin in 1{\%} carrageen-induced paw edema. Moreover, H-PWS co-treatment with indomethacin produced a lower PGE 2 level in serum than only indomethacin. Based on the results, co-treatment with H-PWS reduced the occurrence of indomethacin-induced gastric ulcers without affecting the anti-inflammatory effect of indomethacin. Therefore, we suggested that H-PWS can be developed as an anti-ulcer drug and H-PWS could be taken with indomethacin to decrease ulceration.",
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AU - Liang, Wen Li

AU - Liu, Hsiang Yin

AU - Wang, Kun Teng

AU - Chang, Chun Chao

AU - Wang, Ching Chiung

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