Gastroprotective activities of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) on the growth of the stomach cancer ags cell line and indomethacin-induced gastric ulcers

Cheng Pei Chung, Shih Min Hsia, Ming Yi Lee, Hong Jhang Chen, Faiwen Cheng, Lu Chi Chan, Yueh Hsiung Kuo, Yun Lian Lin, Wenchang Chiang

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43 Citations (Scopus)


Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seeds have long been used to treat warts, chapped skin, rheumatism, and neuralgia in traditional Chinese medicine (TCM). Recently, studies demonstrated its anti-inflammatory, antiproliferative, antitumor, and antiallergic activities. In the present study, we first report the gastroprotective effects of dehulled adlay (DA) seeds, which consist of bran (AB) and endosperm (AE). The DA ethanolic extract (DAE) was prepared, along with the AB and AE ethanolic extracts (ABE and AEE), and the inhibitory effects of these extracts were tested on the AGS gastric cancer cell line. Results indicated that the ABE showed better antiproliferative activity, and 19 compounds were purified from AB in a further phenolic-compound-guided separation. Among the isolated compounds, caffeic and chlorogenic acids significantly suppressed the growth of AGS cells. In addition, the antiulcer activity of DA was examined in an indomethacin-induced gastric lesion model. The ulcer index (UI) and oxidative biomarkers in animals decreased, while the non-protein sulfhydryl (NPSH) groups were elevated when given DA. This is the first investigation of antiulcer activity of adlay, and we demonstrated that the antioxidative-active phenolic acids in DA contribute to some portion of the gastroprotective effects.

Original languageEnglish
Pages (from-to)6025-6033
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Issue number11
Publication statusPublished - Jun 8 2011
Externally publishedYes



  • Adlay
  • adlay bran
  • antiproliferation
  • antiulcer effect
  • dehulled adlay
  • phenolic compounds

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

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