Gastric metaplasia of regenerating duodenal mucosa and deformity of duodenal bulb: A correlative study

Shiann Pan, Gi Shih Lien, Cheng Hsiung Liao, Sheng Hsuan Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The correlation between the presence and degree of gastric metaplasia of regenerating duodenal mucosa and the deformity of duodenal bulb was studied. Based on the endoscopically morphological patterns of bulb, the duodenal ulcers were divided into three types: type I, with a normal-shaped bulb; type II, with a mildly deformed bulb; and type III, with a markedly deformed bulb. A total of 159 patients with active duodenal ulcers were scheduled to be treated with H2-receptor antagonists. Of these patients, 124 proved to have a healed duodenal ulcer 4 weeks after initial treatment upon follow-up endoscopic examinations. Two biopsies were taken from the centre of the ulcer scar when the ulcer was found to be healed for light microscopic study. Histologically, the degree of gastric metaplasia was divided into three grades: grades 0, 1 and 2. The results show that a healed duodenal ulcer with a normal-shaped bulb is not frequently accompanied by gastric metaplasia. However, a healed ulcer with a markedly deformed bulb has a high incidence and degree of gastric metaplasia, which may be easily colonized by Helicobacter pylori and thus develop an environment of easy recurrence. Therefore, a cycle of healing and recurrence may exist in patients with a duodenal ulcer and a markedly deformed bulb. Eradication of H. pylori may be the best way to break this cycle.

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume11
Issue number2
DOIs
Publication statusPublished - Jan 1 1996

Keywords

  • Bulbar deformity
  • Duodenal ulcer
  • Gastric metaplasia
  • Regenerating mucosa

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Gastric metaplasia of regenerating duodenal mucosa and deformity of duodenal bulb: A correlative study'. Together they form a unique fingerprint.

  • Cite this