Abstract
Undifferentiated gastric carcinoma with prominent lymphoid infiltration and a striking resemblance to nasopharyngeal lymphoepithelioma has rarely been reported. Recently, the Epstein-Barr virus (EBV) genome has been demonstrated in some cases of gastric carcinoma with a morphology similar to undifferentiated nasopharyngeal carcinoma (NPC). One such case has been identified here by immunohistochemistry; it was explored for the EBV genome by RNA in situ hybridization (ISH) with an EBERs (Epstein-Barr virus encoded RNAs) probe. EBV RNAs were detected uniformly in the carcinoma cells or adjacent dysplasia epithelium, but were not present in the related lymphoid infiltration or in normal gastric mucosa. These findings add to the growing body of evidence suggesting the strong association of EBV with gastric lympho-epithelioma-like carcinoma (LELC), and also indicate that a latent EBV infection may play a role in undifferentiated epithelial cells.
| Original language | English |
|---|---|
| Pages (from-to) | 282-285 |
| Number of pages | 4 |
| Journal | Chinese Medical Journal (Taipei) |
| Volume | 54 |
| Issue number | 4 |
| Publication status | Published - Oct 1994 |
| Externally published | Yes |
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Cite this
Gastric lymphoepithelioma-like carcinoma associated with Epstein-Barr virus proved by in situ hybridization study : a case report. / Harn, H. J.; Ho, L. I.; Lee, H. S.; Lee, W. H.
In: Chinese Medical Journal (Taipei), Vol. 54, No. 4, 10.1994, p. 282-285.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gastric lymphoepithelioma-like carcinoma associated with Epstein-Barr virus proved by in situ hybridization study
T2 - a case report.
AU - Harn, H. J.
AU - Ho, L. I.
AU - Lee, H. S.
AU - Lee, W. H.
PY - 1994/10
Y1 - 1994/10
N2 - Undifferentiated gastric carcinoma with prominent lymphoid infiltration and a striking resemblance to nasopharyngeal lymphoepithelioma has rarely been reported. Recently, the Epstein-Barr virus (EBV) genome has been demonstrated in some cases of gastric carcinoma with a morphology similar to undifferentiated nasopharyngeal carcinoma (NPC). One such case has been identified here by immunohistochemistry; it was explored for the EBV genome by RNA in situ hybridization (ISH) with an EBERs (Epstein-Barr virus encoded RNAs) probe. EBV RNAs were detected uniformly in the carcinoma cells or adjacent dysplasia epithelium, but were not present in the related lymphoid infiltration or in normal gastric mucosa. These findings add to the growing body of evidence suggesting the strong association of EBV with gastric lympho-epithelioma-like carcinoma (LELC), and also indicate that a latent EBV infection may play a role in undifferentiated epithelial cells.
AB - Undifferentiated gastric carcinoma with prominent lymphoid infiltration and a striking resemblance to nasopharyngeal lymphoepithelioma has rarely been reported. Recently, the Epstein-Barr virus (EBV) genome has been demonstrated in some cases of gastric carcinoma with a morphology similar to undifferentiated nasopharyngeal carcinoma (NPC). One such case has been identified here by immunohistochemistry; it was explored for the EBV genome by RNA in situ hybridization (ISH) with an EBERs (Epstein-Barr virus encoded RNAs) probe. EBV RNAs were detected uniformly in the carcinoma cells or adjacent dysplasia epithelium, but were not present in the related lymphoid infiltration or in normal gastric mucosa. These findings add to the growing body of evidence suggesting the strong association of EBV with gastric lympho-epithelioma-like carcinoma (LELC), and also indicate that a latent EBV infection may play a role in undifferentiated epithelial cells.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028524844&partnerID=8YFLogxK
M3 - Article
C2 - 7982142
AN - SCOPUS:0028524844
VL - 54
SP - 282
EP - 285
JO - Journal of the Chinese Medical Association
JF - Journal of the Chinese Medical Association
SN - 1726-4901
IS - 4
ER -