Gastric lymphoepithelioma-like carcinoma associated with Epstein-Barr virus proved by in situ hybridization study: a case report.

H. J. Harn, L. I. Ho, H. S. Lee, W. H. Lee

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Abstract

Undifferentiated gastric carcinoma with prominent lymphoid infiltration and a striking resemblance to nasopharyngeal lymphoepithelioma has rarely been reported. Recently, the Epstein-Barr virus (EBV) genome has been demonstrated in some cases of gastric carcinoma with a morphology similar to undifferentiated nasopharyngeal carcinoma (NPC). One such case has been identified here by immunohistochemistry; it was explored for the EBV genome by RNA in situ hybridization (ISH) with an EBERs (Epstein-Barr virus encoded RNAs) probe. EBV RNAs were detected uniformly in the carcinoma cells or adjacent dysplasia epithelium, but were not present in the related lymphoid infiltration or in normal gastric mucosa. These findings add to the growing body of evidence suggesting the strong association of EBV with gastric lympho-epithelioma-like carcinoma (LELC), and also indicate that a latent EBV infection may play a role in undifferentiated epithelial cells.

Original languageEnglish
Pages (from-to)282-285
Number of pages4
JournalChinese Medical Journal (Taipei)
Volume54
Issue number4
Publication statusPublished - Oct 1994
Externally publishedYes

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Human Herpesvirus 4
In Situ Hybridization
Stomach
Carcinoma
Genome
RNA
RNA Probes
Epstein-Barr Virus Infections
Gastric Mucosa
Epithelium
Epithelial Cells
Immunohistochemistry

ASJC Scopus subject areas

  • Medicine(all)

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Gastric lymphoepithelioma-like carcinoma associated with Epstein-Barr virus proved by in situ hybridization study : a case report. / Harn, H. J.; Ho, L. I.; Lee, H. S.; Lee, W. H.

In: Chinese Medical Journal (Taipei), Vol. 54, No. 4, 10.1994, p. 282-285.

Research output: Contribution to journalArticle

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