Gastric bleeding due to graft-vs-host disease

Discrepancy between endoscopic and histologic assessment

Su Peng Yeh, Yu Mine Liao, Chang Hu Hsu, Chi Long Chen, Ying Chun Shen, Chung Tsen Hsueh, Hsin Hui Huang, Chiao Lin Lin, Chang Fang Chiu

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Gastric bleeding due to graft-vs-host-disease (GVHD) is rare after allogeneic hematopoietic stem cell transplantation, and the interrelationship between endoscopic and histologic assessment has not been well studied. Four patients with documented gastric bleeding due to GVHD were evaluated retrospectively. The endoscopic findings varied markedly and included mild mucosal edema with focal erythema, diffuse erythema with mucosal oozing, and diffuse polypoid indurations with multiple bleeding ulcerations. The histologic features of endoscopic biopsy specimens also varied from scattered apoptotic epithelial cells in one end to denudation of the epithelium with crypt necrosis in the other. The endoscopic findings could not accurately predict the histologic grading of GVHD. Nevertheless, gastric bleeding resolved in 3 patients with increasing intensity of immunosuppression. There was significant disparity between the endoscopic and histologic assessment of the severity of GVHD, and careful adjustment of immunosuppressive therapy might be warranted.

Original languageEnglish
Pages (from-to)919-925
Number of pages7
JournalAmerican Journal of Clinical Pathology
Volume122
Issue number6
DOIs
Publication statusPublished - Dec 2004
Externally publishedYes

Fingerprint

Graft vs Host Disease
Stomach
Hemorrhage
Erythema
Hematopoietic Stem Cell Transplantation
Immunosuppressive Agents
Immunosuppression
Edema
Necrosis
Epithelium
Epithelial Cells
Biopsy
Therapeutics

Keywords

  • Endoscopy
  • Graft-vs-host disease
  • GVHD
  • Stomach
  • Transplantation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Gastric bleeding due to graft-vs-host disease : Discrepancy between endoscopic and histologic assessment. / Yeh, Su Peng; Liao, Yu Mine; Hsu, Chang Hu; Chen, Chi Long; Shen, Ying Chun; Hsueh, Chung Tsen; Huang, Hsin Hui; Lin, Chiao Lin; Chiu, Chang Fang.

In: American Journal of Clinical Pathology, Vol. 122, No. 6, 12.2004, p. 919-925.

Research output: Contribution to journalArticle

Yeh, Su Peng ; Liao, Yu Mine ; Hsu, Chang Hu ; Chen, Chi Long ; Shen, Ying Chun ; Hsueh, Chung Tsen ; Huang, Hsin Hui ; Lin, Chiao Lin ; Chiu, Chang Fang. / Gastric bleeding due to graft-vs-host disease : Discrepancy between endoscopic and histologic assessment. In: American Journal of Clinical Pathology. 2004 ; Vol. 122, No. 6. pp. 919-925.
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