Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo

Shih Chung Hsu, Chien Chih Ou, Tzu Chao Chuang, Jhy Wei Li, Yi Jen Lee, Vinchi Wang, Jah Yao Liu, Chin Shiang Chen, Song Chow Lin, Ming Ching Kao

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Abstract

We examined the anti-angiogenic effects of Ganoderma tsugae methanol extract (GTME) on human epidermoid carcinoma A-431 cells. Our data indicate that GTME inhibits the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in vitro and in vivo, and also inhibits the capillary tube formation of human umbilical vein endothelial cells (HUVECs). We also show that the suppression of VEGF expression by GTME can be restored by treatment with EGF. These results suggest that GTME inhibits VEGF expression via the suppression of EGFR expression, resulting in the downregulation of VEGF secretion from epidermoid carcinoma A-431 cells. These findings reveal a novel role for G. tsugae in inhibiting EGFR and VEGF expression, which are important for tumor angiogenesis and growth. Thus, GTME may provide a potential therapeutic approach for anti-tumor treatment.

Original languageEnglish
Pages (from-to)108-116
Number of pages9
JournalCancer Letters
Volume281
Issue number1
DOIs
Publication statusPublished - Aug 18 2009

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Keywords

  • Anti-angiogenesis
  • Epidermal growth factor receptor
  • Epidermoid carcinoma
  • Ganoderma tsugae
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hsu, S. C., Ou, C. C., Chuang, T. C., Li, J. W., Lee, Y. J., Wang, V., Liu, J. Y., Chen, C. S., Lin, S. C., & Kao, M. C. (2009). Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells: In vitro and in vivo. Cancer Letters, 281(1), 108-116. https://doi.org/10.1016/j.canlet.2009.02.032