Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells

In vitro and in vivo

Shih Chung Hsu, Chien Chih Ou, Tzu Chao Chuang, Jhy Wei Li, Yi Jen Lee, Vinchi Wang, Jah Yao Liu, Chin Shiang Chen, Song Chow Lin, Ming Ching Kao

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We examined the anti-angiogenic effects of Ganoderma tsugae methanol extract (GTME) on human epidermoid carcinoma A-431 cells. Our data indicate that GTME inhibits the expression of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in vitro and in vivo, and also inhibits the capillary tube formation of human umbilical vein endothelial cells (HUVECs). We also show that the suppression of VEGF expression by GTME can be restored by treatment with EGF. These results suggest that GTME inhibits VEGF expression via the suppression of EGFR expression, resulting in the downregulation of VEGF secretion from epidermoid carcinoma A-431 cells. These findings reveal a novel role for G. tsugae in inhibiting EGFR and VEGF expression, which are important for tumor angiogenesis and growth. Thus, GTME may provide a potential therapeutic approach for anti-tumor treatment.

Original languageEnglish
Pages (from-to)108-116
Number of pages9
JournalCancer Letters
Volume281
Issue number1
DOIs
Publication statusPublished - Aug 18 2009

Fingerprint

Ganoderma
Epidermal Growth Factor Receptor
Squamous Cell Carcinoma
Vascular Endothelial Growth Factor A
Methanol
Human Umbilical Vein Endothelial Cells
Epidermal Growth Factor
In Vitro Techniques
Neoplasms
Down-Regulation
Growth

Keywords

  • Anti-angiogenesis
  • Epidermal growth factor receptor
  • Epidermoid carcinoma
  • Ganoderma tsugae
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells : In vitro and in vivo. / Hsu, Shih Chung; Ou, Chien Chih; Chuang, Tzu Chao; Li, Jhy Wei; Lee, Yi Jen; Wang, Vinchi; Liu, Jah Yao; Chen, Chin Shiang; Lin, Song Chow; Kao, Ming Ching.

In: Cancer Letters, Vol. 281, No. 1, 18.08.2009, p. 108-116.

Research output: Contribution to journalArticle

Hsu, Shih Chung ; Ou, Chien Chih ; Chuang, Tzu Chao ; Li, Jhy Wei ; Lee, Yi Jen ; Wang, Vinchi ; Liu, Jah Yao ; Chen, Chin Shiang ; Lin, Song Chow ; Kao, Ming Ching. / Ganoderma tsugae extract inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells : In vitro and in vivo. In: Cancer Letters. 2009 ; Vol. 281, No. 1. pp. 108-116.
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AU - Li, Jhy Wei

AU - Lee, Yi Jen

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