Ganoderma formosanum exopolysaccharides inhibit tumor growth via immunomodulation

Hsing Chun Kuo, Yen Wenn Liu, Chi Chin Lum, Kai Di Hsu, Shin Ping Lin, Chang Wei Hsieh, Hui Wen Lin, Tze Ying Lu, Kuan Chen Cheng

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Ganoderma formosanum (GF) is a medicinal mushroom endemic to Taiwan. Previous research established the optimal culture conditions to produce exopolysaccharide rich in β-glucan (GF-EPS) from submerged fermentation of GF. The present study investigated the antitumor effects of GF-EPS in a Lewis lung carcinoma cell (LLC1) tumor-bearing mice model. In the preventive model, GF-EPS was orally administered to mice before LLC1 injection. In the therapeutic model, GF-EPS oral administration was initiated five days after tumor cell injection. The tumor size and body weight of the mice were recorded. After sacrifice, the lymphocyte subpopulation was analyzed using flow cytometry. Spleen tissues were used to analyze cytokine mRNA expression. The results showed that GF-EPS (80 mg/kg) effectively suppressed LLC1 tumor growth in both the preventive and therapeutic models. GF-EPS administration increased the proportion of natural killer cells in the spleen and activated gene expression of several cytokines. Our results provide evidence that GF-EPS promotes tumor inhibition through immunomodulation in tumor-bearing mice.

Original languageEnglish
Article number11251
JournalInternational journal of molecular sciences
Volume22
Issue number20
DOIs
Publication statusPublished - Oct 1 2021

Keywords

  • Cytokine
  • Exopolysaccharides (EPS)
  • Ganoderma formosanum
  • Immunomodulation
  • Natural killer cells

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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