Abstract
Gamma-oryzanol is a component of rice bran oil (RBO) with purported health benefits. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes (T2DM). The rats were divided into three groups and consumed one of the following diets for 5 weeks: 15% soybean oil (control group); 15% palm oil (PO); and 15% PO with the addition of 5.25 g gamma-oryzanol (POO). The results showed that PO markedly increased plasma low-density-lipoprotein cholesterol, plasma triglycerides, and hepatic triglyceride levels, but did not reduce the area under the curve for glucose and insulin significantly, compared with the control group. Adding gamma-oryzanol to PO improved the negative influence of PO on lipid metabolism in T2DM rats. In addition, gamma-oryzanol tended to increase insulin sensitivity in T2DM rats compared to control and PO groups. Longer-term studies are needed to evaluate these effects further.
| Original language | English |
|---|---|
| Pages (from-to) | 45-53 |
| Number of pages | 9 |
| Journal | International Journal for Vitamin and Nutrition Research |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- Gamma-oryzanol
- Insulin resistance
- Lipid metabolism
- Palm oil
- Type 2 diabetes mellitus
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Cite this
Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes. / Cheng, Hsing Hsien; Ma, Chien Y.; Chou, Tsui W.; Chen, Ya Y.; Lai, Ming Hoang.
In: International Journal for Vitamin and Nutrition Research, Vol. 80, No. 1, 2010, p. 45-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes
AU - Cheng, Hsing Hsien
AU - Ma, Chien Y.
AU - Chou, Tsui W.
AU - Chen, Ya Y.
AU - Lai, Ming Hoang
PY - 2010
Y1 - 2010
N2 - Gamma-oryzanol is a component of rice bran oil (RBO) with purported health benefits. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes (T2DM). The rats were divided into three groups and consumed one of the following diets for 5 weeks: 15% soybean oil (control group); 15% palm oil (PO); and 15% PO with the addition of 5.25 g gamma-oryzanol (POO). The results showed that PO markedly increased plasma low-density-lipoprotein cholesterol, plasma triglycerides, and hepatic triglyceride levels, but did not reduce the area under the curve for glucose and insulin significantly, compared with the control group. Adding gamma-oryzanol to PO improved the negative influence of PO on lipid metabolism in T2DM rats. In addition, gamma-oryzanol tended to increase insulin sensitivity in T2DM rats compared to control and PO groups. Longer-term studies are needed to evaluate these effects further.
AB - Gamma-oryzanol is a component of rice bran oil (RBO) with purported health benefits. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes (T2DM). The rats were divided into three groups and consumed one of the following diets for 5 weeks: 15% soybean oil (control group); 15% palm oil (PO); and 15% PO with the addition of 5.25 g gamma-oryzanol (POO). The results showed that PO markedly increased plasma low-density-lipoprotein cholesterol, plasma triglycerides, and hepatic triglyceride levels, but did not reduce the area under the curve for glucose and insulin significantly, compared with the control group. Adding gamma-oryzanol to PO improved the negative influence of PO on lipid metabolism in T2DM rats. In addition, gamma-oryzanol tended to increase insulin sensitivity in T2DM rats compared to control and PO groups. Longer-term studies are needed to evaluate these effects further.
KW - Gamma-oryzanol
KW - Insulin resistance
KW - Lipid metabolism
KW - Palm oil
KW - Type 2 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=77953512873&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953512873&partnerID=8YFLogxK
U2 - 10.1024/0300-9831/a000005
DO - 10.1024/0300-9831/a000005
M3 - Article
C2 - 20533244
AN - SCOPUS:77953512873
VL - 80
SP - 45
EP - 53
JO - Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie
JF - Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie
SN - 0300-9831
IS - 1
ER -