Abstract
Gamma-oryzanol is a component of rice bran oil (RBO) with purported health benefits. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes (T2DM). The rats were divided into three groups and consumed one of the following diets for 5 weeks: 15% soybean oil (control group); 15% palm oil (PO); and 15% PO with the addition of 5.25 g gamma-oryzanol (POO). The results showed that PO markedly increased plasma low-density-lipoprotein cholesterol, plasma triglycerides, and hepatic triglyceride levels, but did not reduce the area under the curve for glucose and insulin significantly, compared with the control group. Adding gamma-oryzanol to PO improved the negative influence of PO on lipid metabolism in T2DM rats. In addition, gamma-oryzanol tended to increase insulin sensitivity in T2DM rats compared to control and PO groups. Longer-term studies are needed to evaluate these effects further.
| Original language | English |
|---|---|
| Pages (from-to) | 45-53 |
| Number of pages | 9 |
| Journal | International Journal for Vitamin and Nutrition Research |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
Keywords
- Gamma-oryzanol
- Insulin resistance
- Lipid metabolism
- Palm oil
- Type 2 diabetes mellitus
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
