Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes

Hsing Hsien Cheng, Chien Y. Ma, Tsui W. Chou, Ya Y. Chen, Ming Hoang Lai

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Gamma-oryzanol is a component of rice bran oil (RBO) with purported health benefits. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes (T2DM). The rats were divided into three groups and consumed one of the following diets for 5 weeks: 15% soybean oil (control group); 15% palm oil (PO); and 15% PO with the addition of 5.25 g gamma-oryzanol (POO). The results showed that PO markedly increased plasma low-density-lipoprotein cholesterol, plasma triglycerides, and hepatic triglyceride levels, but did not reduce the area under the curve for glucose and insulin significantly, compared with the control group. Adding gamma-oryzanol to PO improved the negative influence of PO on lipid metabolism in T2DM rats. In addition, gamma-oryzanol tended to increase insulin sensitivity in T2DM rats compared to control and PO groups. Longer-term studies are needed to evaluate these effects further.

Original languageEnglish
Pages (from-to)45-53
Number of pages9
JournalInternational Journal for Vitamin and Nutrition Research
Volume80
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Niacinamide
Streptozocin
Hyperlipidemias
Type 2 Diabetes Mellitus
Insulin Resistance
Lipid Metabolism
Triglycerides
Control Groups
Soybean Oil
Insurance Benefits
LDL Cholesterol
Area Under Curve
gamma-oryzanol
palm oil
Wistar Rats
Insulin
Diet
Glucose
Liver

Keywords

  • Gamma-oryzanol
  • Insulin resistance
  • Lipid metabolism
  • Palm oil
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes. / Cheng, Hsing Hsien; Ma, Chien Y.; Chou, Tsui W.; Chen, Ya Y.; Lai, Ming Hoang.

In: International Journal for Vitamin and Nutrition Research, Vol. 80, No. 1, 2010, p. 45-53.

Research output: Contribution to journalArticle

Cheng, Hsing Hsien ; Ma, Chien Y. ; Chou, Tsui W. ; Chen, Ya Y. ; Lai, Ming Hoang. / Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes. In: International Journal for Vitamin and Nutrition Research. 2010 ; Vol. 80, No. 1. pp. 45-53.
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