Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes

Hsing Hsien Cheng; Chien Y. Ma; Tsui W. Chou; Ya Y. Chen; Ming Hoang Lai

doi:10.1024/0300-9831/a000005

Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes

Hsing Hsien Cheng, Chien Y. Ma, Tsui W. Chou, Ya Y. Chen, Ming Hoang Lai

School of Nutrition and Health Sciences

Research output: Contribution to journal › Article

22 Citations (Scopus)

Abstract

Gamma-oryzanol is a component of rice bran oil (RBO) with purported health benefits. This study evaluated the effects of gamma-oryzanol on insulin resistance and lipid metabolism in Wistar rats with type 2 diabetes (T2DM). The rats were divided into three groups and consumed one of the following diets for 5 weeks: 15% soybean oil (control group); 15% palm oil (PO); and 15% PO with the addition of 5.25 g gamma-oryzanol (POO). The results showed that PO markedly increased plasma low-density-lipoprotein cholesterol, plasma triglycerides, and hepatic triglyceride levels, but did not reduce the area under the curve for glucose and insulin significantly, compared with the control group. Adding gamma-oryzanol to PO improved the negative influence of PO on lipid metabolism in T2DM rats. In addition, gamma-oryzanol tended to increase insulin sensitivity in T2DM rats compared to control and PO groups. Longer-term studies are needed to evaluate these effects further.

Original language	English
Pages (from-to)	45-53
Number of pages	9
Journal	International Journal for Vitamin and Nutrition Research
Volume	80
Issue number	1
DOIs	https://doi.org/10.1024/0300-9831/a000005
Publication status	Published - 2010

Keywords

Gamma-oryzanol
Insulin resistance
Lipid metabolism
Palm oil
Type 2 diabetes mellitus

ASJC Scopus subject areas

Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism
Nutrition and Dietetics

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Cheng, H. H., Ma, C. Y., Chou, T. W., Chen, Y. Y., & Lai, M. H. (2010). Gamma-oryzanol ameliorates insulin resistance and hyperlipidemia in rats with streptozotocin/nicotinamide-induced type 2 diabetes. International Journal for Vitamin and Nutrition Research, 80(1), 45-53. https://doi.org/10.1024/0300-9831/a000005

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keywords = "Gamma-oryzanol, Insulin resistance, Lipid metabolism, Palm oil, Type 2 diabetes mellitus",

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AU - Chen, Ya Y.

AU - Lai, Ming Hoang

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