Gamma knife radiosurgery for central neurocytoma: Retrospective analysis of fourteen cases with a median follow-up period of sixty-five months

Meng Chao Chen, David Hung Chi Pan, Wen Yuh Chung, Kang Du Liu, Yu Shu Yen, Ming Teh Chen, Tai-Tong Wong, Yang Hsin Shih, Hsiu Mei Wu, Wan Yuo Guo, Cheng Ying Shiau, Ling Wei Wang, Chii Wann Lin

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Object: Central neurocytoma (CN) is considered to be a benign neuronal tumor with possible atypical behavior. Microsurgery, radiation therapy (RT) and radiosurgery all have been used in treating this rare disease during the past decade. In this study, the authors present the experience with gamma knife radiosurgery (GKRS) on 14 patients with CN during a median follow-up period of 65 months and document the safety and efficacy of GKRS in the treatment of CN. Methods: Between November 1997 and December 2009, 14 patients pathologically diagnosed with CN were treated with GKRS. Follow-up magnetic resonance imaging (MRI) was performed at 6-month intervals. Tumor volume and adverse radiation effects (ARE) were documented to evaluate tumor response to GKRS. The Karnofsky Performance Scale (KPS) and neurological status were used to assess clinical outcome. The mean radiation dose prescribed to the tumor margin was 12.1 Gy (ranging from 11 to 13 Gy). The mean tumor volume was 19.6 ml (ranging from 3.5 to 48.9 ml). The mean follow-up period was 70 months (ranging from 30 to 140 months), and the median follow-up period was 65 months. Results: Tumor shrinkage was found in all patients at the final MRI follow-up. The mean volume reduction was 69% (ranging from 47 to 87%). No tumor progression, ARE or radiation-related toxicity developed in any of the cases. The KPS scores of all patients were the same or had increased, and the neurological functions were all stable without deterioration at the final follow-up. Conclusion: In our observations, GKRS was found to be an effective and safe alternative as adjuvant therapy for pathology-confirmed CN. The tumor volume and functional outcome can be controlled with a favorable result in long-term observation. Compared with RT and microsurgery, GKRS plays an important role in the treatment of CN as a minimally invasive technique with low morbidity. Regular long-term MRI follow-up should be mandatory to document the tumor response and possible recurrence. Multicenter consortia should be considered for further investigation and evaluation of GKRS for such a rare tumor.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalStereotactic and Functional Neurosurgery
Volume89
Issue number3
DOIs
Publication statusPublished - Jun 1 2011
Externally publishedYes

Fingerprint

Neurocytoma
Radiosurgery
Tumor Burden
Neoplasms
Karnofsky Performance Status
Microsurgery
Radiation Effects
Magnetic Resonance Imaging
Radiotherapy
Radiation
Rare Diseases
Therapeutics
Observation
Pathology
Morbidity
Safety
Recurrence

Keywords

  • Central neurocytoma
  • Gamma knife radiosurgery
  • Radiation effect
  • Radiotherapy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Gamma knife radiosurgery for central neurocytoma : Retrospective analysis of fourteen cases with a median follow-up period of sixty-five months. / Chen, Meng Chao; Pan, David Hung Chi; Chung, Wen Yuh; Liu, Kang Du; Yen, Yu Shu; Chen, Ming Teh; Wong, Tai-Tong; Shih, Yang Hsin; Wu, Hsiu Mei; Guo, Wan Yuo; Shiau, Cheng Ying; Wang, Ling Wei; Lin, Chii Wann.

In: Stereotactic and Functional Neurosurgery, Vol. 89, No. 3, 01.06.2011, p. 185-193.

Research output: Contribution to journalArticle

Chen, MC, Pan, DHC, Chung, WY, Liu, KD, Yen, YS, Chen, MT, Wong, T-T, Shih, YH, Wu, HM, Guo, WY, Shiau, CY, Wang, LW & Lin, CW 2011, 'Gamma knife radiosurgery for central neurocytoma: Retrospective analysis of fourteen cases with a median follow-up period of sixty-five months', Stereotactic and Functional Neurosurgery, vol. 89, no. 3, pp. 185-193. https://doi.org/10.1159/000326780
Chen, Meng Chao ; Pan, David Hung Chi ; Chung, Wen Yuh ; Liu, Kang Du ; Yen, Yu Shu ; Chen, Ming Teh ; Wong, Tai-Tong ; Shih, Yang Hsin ; Wu, Hsiu Mei ; Guo, Wan Yuo ; Shiau, Cheng Ying ; Wang, Ling Wei ; Lin, Chii Wann. / Gamma knife radiosurgery for central neurocytoma : Retrospective analysis of fourteen cases with a median follow-up period of sixty-five months. In: Stereotactic and Functional Neurosurgery. 2011 ; Vol. 89, No. 3. pp. 185-193.
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AU - Pan, David Hung Chi

AU - Chung, Wen Yuh

AU - Liu, Kang Du

AU - Yen, Yu Shu

AU - Chen, Ming Teh

AU - Wong, Tai-Tong

AU - Shih, Yang Hsin

AU - Wu, Hsiu Mei

AU - Guo, Wan Yuo

AU - Shiau, Cheng Ying

AU - Wang, Ling Wei

AU - Lin, Chii Wann

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N2 - Object: Central neurocytoma (CN) is considered to be a benign neuronal tumor with possible atypical behavior. Microsurgery, radiation therapy (RT) and radiosurgery all have been used in treating this rare disease during the past decade. In this study, the authors present the experience with gamma knife radiosurgery (GKRS) on 14 patients with CN during a median follow-up period of 65 months and document the safety and efficacy of GKRS in the treatment of CN. Methods: Between November 1997 and December 2009, 14 patients pathologically diagnosed with CN were treated with GKRS. Follow-up magnetic resonance imaging (MRI) was performed at 6-month intervals. Tumor volume and adverse radiation effects (ARE) were documented to evaluate tumor response to GKRS. The Karnofsky Performance Scale (KPS) and neurological status were used to assess clinical outcome. The mean radiation dose prescribed to the tumor margin was 12.1 Gy (ranging from 11 to 13 Gy). The mean tumor volume was 19.6 ml (ranging from 3.5 to 48.9 ml). The mean follow-up period was 70 months (ranging from 30 to 140 months), and the median follow-up period was 65 months. Results: Tumor shrinkage was found in all patients at the final MRI follow-up. The mean volume reduction was 69% (ranging from 47 to 87%). No tumor progression, ARE or radiation-related toxicity developed in any of the cases. The KPS scores of all patients were the same or had increased, and the neurological functions were all stable without deterioration at the final follow-up. Conclusion: In our observations, GKRS was found to be an effective and safe alternative as adjuvant therapy for pathology-confirmed CN. The tumor volume and functional outcome can be controlled with a favorable result in long-term observation. Compared with RT and microsurgery, GKRS plays an important role in the treatment of CN as a minimally invasive technique with low morbidity. Regular long-term MRI follow-up should be mandatory to document the tumor response and possible recurrence. Multicenter consortia should be considered for further investigation and evaluation of GKRS for such a rare tumor.

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