Gallstone disease and the risk of stroke: A nationwide population-based study

Cheng Yu Wei, Tieh Chi Chung, Chien Hua Chen, Che Chen Lin, Fung Chang Sung, Wen Ting Chung, Woon Man Kung, Chung Y. Hsu, Yung Hsiang Yeh

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19 Citations (Scopus)

Abstract

Background Gallstone disease (GD) and stroke share a number of risk factors including diabetes and hyperlipidemia. This nationwide population-based study was designed to estimate the risk of stroke after a diagnosis of GD. Methods Data were obtained from the Taiwan National Health Insurance Research Database. A total of 135,512 patients with a diagnosis of GD and 271,024 age- and gender-matched non-GD control patients were included to assess the risk of stroke using Cox proportional hazard regression. Results During the study period (2000-2003), 12,234 (153.67/10,000 person-years) strokes occurred among the GD patients, and 20,680 (114.83/10,000 person-years) among the controls. The diagnosis of GD carried a higher risk of developing ischemic and hemorrhagic stroke, with a hazard ratio (HR) of 1.28 and 1.33 (95% confidence interval [CI], 1.25-1.31 and 1.25-1.41, both P

Original languageEnglish
Pages (from-to)1813-1820
Number of pages8
JournalJournal of Stroke and Cerebrovascular Diseases
Volume23
Issue number7
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Keywords

  • cholelithiasis
  • epidemiology
  • gallstone disease
  • risk factors
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Rehabilitation
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Wei, C. Y., Chung, T. C., Chen, C. H., Lin, C. C., Sung, F. C., Chung, W. T., Kung, W. M., Hsu, C. Y., & Yeh, Y. H. (2014). Gallstone disease and the risk of stroke: A nationwide population-based study. Journal of Stroke and Cerebrovascular Diseases, 23(7), 1813-1820. https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.04.024