Galloway-Mowat syndrome: A glomerular basement membrane disorder?

Chun Chen Lin, Jeng Daw Tsai, Shuan Pei Lin, Chin Yuan Tzen, Ein Yiao Shen, Chien Sheng Shih

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13 Citations (Scopus)

Abstract

We report a female infant with Galloway-Mowat syndrome. In addition to the characteristic dysmorphic appearance, neurological anomalies and early-onset nephrotic syndrome, she had arachnodactyly, an observation thus far reported uniquely in Taiwan. Also, her elder sister had the same condition. Renal pathology on light microscopy showed cystic dilatation of the renal tubules. Electron microscopy showed an irregular glomerular basement membrane and effacement of foot processes. This observation suggests that malformation of the glomerular basement membrane may cause the glomerulopathy in Galloway-Mowat syndrome.

Original languageEnglish
Pages (from-to)653-657
Number of pages5
JournalPediatric Nephrology
Volume16
Issue number8
DOIs
Publication statusPublished - 2001
Externally publishedYes

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Keywords

  • Arachnodactyly
  • Effacement of foot processes
  • Galloway-Mowat syndrome
  • Glomerular basement membrane disorder
  • Irregular thickness of glomerular basement membrane

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Lin, C. C., Tsai, J. D., Lin, S. P., Tzen, C. Y., Shen, E. Y., & Shih, C. S. (2001). Galloway-Mowat syndrome: A glomerular basement membrane disorder? Pediatric Nephrology, 16(8), 653-657. https://doi.org/10.1007/s004670100628