Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents

Yu Shen Lin, Yann Hung, Jen Kuan Su, Rain Lee, Chen Chang, Meng Liang Lin, Chung Yuan Mou

Research output: Contribution to journalArticlepeer-review

128 Citations (Scopus)

Abstract

A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using long-chain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, 29Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r1 and r2, than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.

Original languageEnglish
Pages (from-to)15608-15611
Number of pages4
JournalJournal of Physical Chemistry B
Volume108
Issue number40
DOIs
Publication statusPublished - Oct 7 2004
Externally publishedYes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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