GABAergic neuron death in the striatum following kainate-induced damage of hippocampal neurons: Evidence for the role of no in locomotion

Yang Hsin Shih, Ai Wei Lee, Yn Ho Huang, Miau Hwa Ko, Yu Show Fu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The authors examined the role of nitric oxide (NO) in the relationship between kainate-induced neuronal death and locomotion changes. Locomotion was significantly increased 1 h after kainate injection, suggesting that kainate induced NO and dopamine release. Cell death occurred in the CA1 (41%) and CA3 (54%) regions at 12 h. At 7 days, GABAergic neurons in striatum were lost, suggesting possible pyramidal neuron synapse with striatal GABAergic neurons, and pyramidal neuron damage leading to deafferentation and degeneration of striatal GABAergic neurons. Pre-administration of Nw-nitro-L- arginine-methyl-ester or 7-nitroindazole reduced these effects. These results indicate that NO may modulate kainate-induced neuronal death and locomotion.

Original languageEnglish
Pages (from-to)1119-1132
Number of pages14
JournalInternational Journal of Neuroscience
Volume114
Issue number9
DOIs
Publication statusPublished - Sep 2004
Externally publishedYes

Keywords

  • 7-nitroindazole
  • Kainate
  • Locomotion
  • N-nitro-L- arginine methyl ester
  • Neuronal death
  • NO

ASJC Scopus subject areas

  • Neuroscience(all)

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