GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing

A combined fMRI/MEG study with placebo and lorazepam

Georg Northoff, Thomas Witzel, Andre Richter, Matthias Gessner, Florian Schlagenhauf, Jürgen Fell, Frank Baumgart, Thomas Kaulisch, Claus Tempelmann, Alexander Heinzel, Rolf Kötter, Tilman Hagner, Bela Bargel, Hermann Hinrichs, Bernhard Bogerts, Henning Scheich, Hans Jochen Heinze

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Various prefrontal cortical regions have been shown to be activated during emotional stimulation, whereas neurochemical mechanisms underlying emotional processing in the prefrontal cortex remain unclear. We therefore investigated the influence of the GABA-A potentiator lorazepam on prefrontal cortical emotional-motor spatio-temporal activation pattern in a combined functional magnetic resonance imaging/magnetoencephalography study. Lorazepam led to the reversal in orbito-frontal activation pattern, a shift of the early magnetic field dipole from the orbito-frontal to medial prefrontal cortex, and alterations in premotor/motor cortical function during negative and positive emotional stimulation. It is concluded that negative emotional processing in the orbito-frontal cortex may be modulated either directly or indirectly by GABA-A receptors. Such a modulation of orbito-frontal cortical emotional function by lorazepam has to be distinguished from its effects on cortical motor function as being independent from the kind of processing either emotional or nonemotional.

Original languageEnglish
Pages (from-to)348-370
Number of pages23
JournalJournal of Cognitive Neuroscience
Volume14
Issue number3
DOIs
Publication statusPublished - Apr 1 2002
Externally publishedYes

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Lorazepam
gamma-Aminobutyric Acid
Placebos
Magnetic Resonance Imaging
Prefrontal Cortex
Magnetoencephalography
Frontal Lobe
GABA-A Receptors
Magnetic Fields

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Cite this

GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing : A combined fMRI/MEG study with placebo and lorazepam. / Northoff, Georg; Witzel, Thomas; Richter, Andre; Gessner, Matthias; Schlagenhauf, Florian; Fell, Jürgen; Baumgart, Frank; Kaulisch, Thomas; Tempelmann, Claus; Heinzel, Alexander; Kötter, Rolf; Hagner, Tilman; Bargel, Bela; Hinrichs, Hermann; Bogerts, Bernhard; Scheich, Henning; Heinze, Hans Jochen.

In: Journal of Cognitive Neuroscience, Vol. 14, No. 3, 01.04.2002, p. 348-370.

Research output: Contribution to journalArticle

Northoff, G, Witzel, T, Richter, A, Gessner, M, Schlagenhauf, F, Fell, J, Baumgart, F, Kaulisch, T, Tempelmann, C, Heinzel, A, Kötter, R, Hagner, T, Bargel, B, Hinrichs, H, Bogerts, B, Scheich, H & Heinze, HJ 2002, 'GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: A combined fMRI/MEG study with placebo and lorazepam', Journal of Cognitive Neuroscience, vol. 14, no. 3, pp. 348-370. https://doi.org/10.1162/089892902317361895
Northoff, Georg ; Witzel, Thomas ; Richter, Andre ; Gessner, Matthias ; Schlagenhauf, Florian ; Fell, Jürgen ; Baumgart, Frank ; Kaulisch, Thomas ; Tempelmann, Claus ; Heinzel, Alexander ; Kötter, Rolf ; Hagner, Tilman ; Bargel, Bela ; Hinrichs, Hermann ; Bogerts, Bernhard ; Scheich, Henning ; Heinze, Hans Jochen. / GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing : A combined fMRI/MEG study with placebo and lorazepam. In: Journal of Cognitive Neuroscience. 2002 ; Vol. 14, No. 3. pp. 348-370.
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