GABA a receptors predict aversion-related brain responses

An fMRI-PET investigation in healthy humans

Dave J. Hayes, Niall W. Duncan, Christine Wiebking, Karin Pietruska, Pengmin Qin, Stefan Lang, Jean Gagnon, Paul Gravel Bing, Jeroen Verhaeghe, Alexey P. Kostikov, Ralf Schirrmacher, Andrew J. Reader, Julien Doyon, Pierre Rainville, Georg Northoff

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The perception of aversive stimuli is essential for human survival and depends largely on environmental context. Although aversive brain processing has been shown to involve the sensorimotor cortex, the neural and biochemical mechanisms underlying the interaction between two independent aversive cues are unclear. Based on previous work indicating ventromedial prefrontal cortex (vmPFC) involvement in the mediation of context-dependent emotional effects, we hypothesized a central role for the vmPFC in modulating sensorimotor cortex activity using a GABAergic mechanism during an aversive-aversive stimulus interaction. This approach revealed differential activations within the aversion-related network (eg, sensorimotor cortex, midcingulate, and insula) for the aversive-aversive, when compared with the aversive-neutral, interaction. Individual differences in sensorimotor cortex signal changes during the aversive-aversive interaction were predicted by GABA A receptors in both vmPFC and sensorimotor cortex. Together, these results demonstrate the central role of GABA in mediating context-dependent effects in aversion-related processing.

Original languageEnglish
Pages (from-to)1438-1450
Number of pages13
JournalNeuropsychopharmacology
Volume38
Issue number8
DOIs
Publication statusPublished - Jul 2013
Externally publishedYes

Fingerprint

GABA Receptors
Magnetic Resonance Imaging
Prefrontal Cortex
Brain
GABA-A Receptors
Individuality
gamma-Aminobutyric Acid
Cues
Sensorimotor Cortex
Survival

Keywords

  • emotion
  • flumazenil
  • fMRI
  • human
  • perigenual anterior cingulate cortex
  • PET

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

GABA a receptors predict aversion-related brain responses : An fMRI-PET investigation in healthy humans. / Hayes, Dave J.; Duncan, Niall W.; Wiebking, Christine; Pietruska, Karin; Qin, Pengmin; Lang, Stefan; Gagnon, Jean; Bing, Paul Gravel; Verhaeghe, Jeroen; Kostikov, Alexey P.; Schirrmacher, Ralf; Reader, Andrew J.; Doyon, Julien; Rainville, Pierre; Northoff, Georg.

In: Neuropsychopharmacology, Vol. 38, No. 8, 07.2013, p. 1438-1450.

Research output: Contribution to journalArticle

Hayes, DJ, Duncan, NW, Wiebking, C, Pietruska, K, Qin, P, Lang, S, Gagnon, J, Bing, PG, Verhaeghe, J, Kostikov, AP, Schirrmacher, R, Reader, AJ, Doyon, J, Rainville, P & Northoff, G 2013, 'GABA a receptors predict aversion-related brain responses: An fMRI-PET investigation in healthy humans', Neuropsychopharmacology, vol. 38, no. 8, pp. 1438-1450. https://doi.org/10.1038/npp.2013.40
Hayes, Dave J. ; Duncan, Niall W. ; Wiebking, Christine ; Pietruska, Karin ; Qin, Pengmin ; Lang, Stefan ; Gagnon, Jean ; Bing, Paul Gravel ; Verhaeghe, Jeroen ; Kostikov, Alexey P. ; Schirrmacher, Ralf ; Reader, Andrew J. ; Doyon, Julien ; Rainville, Pierre ; Northoff, Georg. / GABA a receptors predict aversion-related brain responses : An fMRI-PET investigation in healthy humans. In: Neuropsychopharmacology. 2013 ; Vol. 38, No. 8. pp. 1438-1450.
@article{45030c0eeb7b4c5f8d3f2a358a890497,
title = "GABA a receptors predict aversion-related brain responses: An fMRI-PET investigation in healthy humans",
abstract = "The perception of aversive stimuli is essential for human survival and depends largely on environmental context. Although aversive brain processing has been shown to involve the sensorimotor cortex, the neural and biochemical mechanisms underlying the interaction between two independent aversive cues are unclear. Based on previous work indicating ventromedial prefrontal cortex (vmPFC) involvement in the mediation of context-dependent emotional effects, we hypothesized a central role for the vmPFC in modulating sensorimotor cortex activity using a GABAergic mechanism during an aversive-aversive stimulus interaction. This approach revealed differential activations within the aversion-related network (eg, sensorimotor cortex, midcingulate, and insula) for the aversive-aversive, when compared with the aversive-neutral, interaction. Individual differences in sensorimotor cortex signal changes during the aversive-aversive interaction were predicted by GABA A receptors in both vmPFC and sensorimotor cortex. Together, these results demonstrate the central role of GABA in mediating context-dependent effects in aversion-related processing.",
keywords = "emotion, flumazenil, fMRI, human, perigenual anterior cingulate cortex, PET",
author = "Hayes, {Dave J.} and Duncan, {Niall W.} and Christine Wiebking and Karin Pietruska and Pengmin Qin and Stefan Lang and Jean Gagnon and Bing, {Paul Gravel} and Jeroen Verhaeghe and Kostikov, {Alexey P.} and Ralf Schirrmacher and Reader, {Andrew J.} and Julien Doyon and Pierre Rainville and Georg Northoff",
year = "2013",
month = "7",
doi = "10.1038/npp.2013.40",
language = "English",
volume = "38",
pages = "1438--1450",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "8",

}

TY - JOUR

T1 - GABA a receptors predict aversion-related brain responses

T2 - An fMRI-PET investigation in healthy humans

AU - Hayes, Dave J.

AU - Duncan, Niall W.

AU - Wiebking, Christine

AU - Pietruska, Karin

AU - Qin, Pengmin

AU - Lang, Stefan

AU - Gagnon, Jean

AU - Bing, Paul Gravel

AU - Verhaeghe, Jeroen

AU - Kostikov, Alexey P.

AU - Schirrmacher, Ralf

AU - Reader, Andrew J.

AU - Doyon, Julien

AU - Rainville, Pierre

AU - Northoff, Georg

PY - 2013/7

Y1 - 2013/7

N2 - The perception of aversive stimuli is essential for human survival and depends largely on environmental context. Although aversive brain processing has been shown to involve the sensorimotor cortex, the neural and biochemical mechanisms underlying the interaction between two independent aversive cues are unclear. Based on previous work indicating ventromedial prefrontal cortex (vmPFC) involvement in the mediation of context-dependent emotional effects, we hypothesized a central role for the vmPFC in modulating sensorimotor cortex activity using a GABAergic mechanism during an aversive-aversive stimulus interaction. This approach revealed differential activations within the aversion-related network (eg, sensorimotor cortex, midcingulate, and insula) for the aversive-aversive, when compared with the aversive-neutral, interaction. Individual differences in sensorimotor cortex signal changes during the aversive-aversive interaction were predicted by GABA A receptors in both vmPFC and sensorimotor cortex. Together, these results demonstrate the central role of GABA in mediating context-dependent effects in aversion-related processing.

AB - The perception of aversive stimuli is essential for human survival and depends largely on environmental context. Although aversive brain processing has been shown to involve the sensorimotor cortex, the neural and biochemical mechanisms underlying the interaction between two independent aversive cues are unclear. Based on previous work indicating ventromedial prefrontal cortex (vmPFC) involvement in the mediation of context-dependent emotional effects, we hypothesized a central role for the vmPFC in modulating sensorimotor cortex activity using a GABAergic mechanism during an aversive-aversive stimulus interaction. This approach revealed differential activations within the aversion-related network (eg, sensorimotor cortex, midcingulate, and insula) for the aversive-aversive, when compared with the aversive-neutral, interaction. Individual differences in sensorimotor cortex signal changes during the aversive-aversive interaction were predicted by GABA A receptors in both vmPFC and sensorimotor cortex. Together, these results demonstrate the central role of GABA in mediating context-dependent effects in aversion-related processing.

KW - emotion

KW - flumazenil

KW - fMRI

KW - human

KW - perigenual anterior cingulate cortex

KW - PET

UR - http://www.scopus.com/inward/record.url?scp=84879419209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879419209&partnerID=8YFLogxK

U2 - 10.1038/npp.2013.40

DO - 10.1038/npp.2013.40

M3 - Article

VL - 38

SP - 1438

EP - 1450

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 8

ER -