G-Protein Coupled Estrogen Receptor in Breast Cancer

Li Han Hsu, Nei Min Chu, Yung Feng Lin, Shu Huei Kao

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer. On the other hand, triple-negative breast cancer (TNBC) constitutes 15% to 20% of breast cancers and frequently displays a more aggressive behavior. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic. A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume20
Issue number2
DOIs
Publication statusPublished - Jan 14 2019

Fingerprint

estrogens
G-Protein-Coupled Receptors
GTP-Binding Proteins
breast
Estrogen Receptors
cancer
Breast Neoplasms
proteins
Proteins
Triple Negative Breast Neoplasms
Estrogens
Tamoxifen
Disease Management
Epidermal Growth Factor Receptor
Tissue

Keywords

  • breast cancer
  • epidermal growth factor receptor
  • estrogen
  • estrogen receptor
  • G-protein coupled estrogen receptor

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

G-Protein Coupled Estrogen Receptor in Breast Cancer. / Hsu, Li Han; Chu, Nei Min; Lin, Yung Feng; Kao, Shu Huei.

In: International Journal of Molecular Sciences, Vol. 20, No. 2, 14.01.2019.

Research output: Contribution to journalReview article

@article{3becc8cde7de4f598d929cd41c2e6377,
title = "G-Protein Coupled Estrogen Receptor in Breast Cancer",
abstract = "The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50{\%} to 60{\%} of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer. On the other hand, triple-negative breast cancer (TNBC) constitutes 15{\%} to 20{\%} of breast cancers and frequently displays a more aggressive behavior. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic. A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future.",
keywords = "breast cancer, epidermal growth factor receptor, estrogen, estrogen receptor, G-protein coupled estrogen receptor",
author = "Hsu, {Li Han} and Chu, {Nei Min} and Lin, {Yung Feng} and Kao, {Shu Huei}",
year = "2019",
month = "1",
day = "14",
doi = "10.3390/ijms20020306",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "2",

}

TY - JOUR

T1 - G-Protein Coupled Estrogen Receptor in Breast Cancer

AU - Hsu, Li Han

AU - Chu, Nei Min

AU - Lin, Yung Feng

AU - Kao, Shu Huei

PY - 2019/1/14

Y1 - 2019/1/14

N2 - The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer. On the other hand, triple-negative breast cancer (TNBC) constitutes 15% to 20% of breast cancers and frequently displays a more aggressive behavior. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic. A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future.

AB - The G-protein coupled estrogen receptor (GPER), an alternate estrogen receptor (ER) with a structure distinct from the two canonical ERs, being ERα, and ERβ, is expressed in 50% to 60% of breast cancer tissues and has been presumed to be associated with the development of tamoxifen resistance in ERα positive breast cancer. On the other hand, triple-negative breast cancer (TNBC) constitutes 15% to 20% of breast cancers and frequently displays a more aggressive behavior. GPER is prevalent and involved in TNBC and can be a therapeutic target. However, contradictory results exist regarding the function of GPER in breast cancer, proliferative or pro-apoptotic. A better understanding of the GPER, its role in breast cancer, and the interactions with the ER and epidermal growth factor receptor will be beneficial for the disease management and prevention in the future.

KW - breast cancer

KW - epidermal growth factor receptor

KW - estrogen

KW - estrogen receptor

KW - G-protein coupled estrogen receptor

UR - http://www.scopus.com/inward/record.url?scp=85060061331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060061331&partnerID=8YFLogxK

U2 - 10.3390/ijms20020306

DO - 10.3390/ijms20020306

M3 - Review article

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 2

ER -