G-CSF rescues the memory impairment of animal models of Alzheimer's disease

Kuen Jer Tsai, Yueh Chiao Tsai, Che Kun James Shen

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Most of the current clinical treatments for Alzheimer's disease (AD) are largely symptomatic and can have serious side effects. We have tested the feasibility of using the granulocyte colony-stimulating factor (G-CSF), which is known to mobilize hematopoietic stem cells (HSCs) from the bone marrow into the peripheral blood, as a therapeutic agent for AD. Subcutaneous administration of G-CSF into two different β-amyloid (Aβ)-induced AD mouse models substantially rescued their cognitive/memory functions. The rescue was accompanied by the accumulation of 5-bromo-2′deoxyuridine-positive HSCs, as well as local neurogenesis surrounding the Aβ aggregates. Furthermore, the level of acetylcholine in the brains of Tg2576 mice was considerably enhanced upon G-CSF treatment. We suggest that G-CSF, a drug already extensively used for treating chemotherapy-induced neutropenia, should be pursued as a novel, noninvasive therapeutic agent for the treatment of AD. JEM

Original languageEnglish
Pages (from-to)1273-1280
Number of pages8
JournalJournal of Experimental Medicine
Volume204
Issue number6
DOIs
Publication statusPublished - Jun 11 2007
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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