Furosemide prevents the renal side effects of indomethacin therapy in premature infants with patent ductus arteriosus

T. F. Yeh, A. Wilks, J. Singh, M. Betkerur, L. Lilien, R. S. Pildes

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

To determine if furosemide would prevent the renal side effects of indomethacin therapy in premature infants with patent ductus arteriosus, 19 premature infants were randomized into two groups: nine received indomethacin alone, and ten received indomethacin followed immediately by furosemide. There was no significant difference between the groups in birth weight, gestational age, postnatal age, and in cardiopulmonary or renal status at the time of study. Infants who received indomethacin and furosemide had significantly higher urine output (P<0.05), higher FENa and FECl (P<0.01), and higher glomerular filtration rate (P<0.05) than those of infants who received indomethacin alone. Seven infants in each group responded to indomethacin therapy with disappearance of PDA murmur and improvement of cardiovascular status. The results of this study suggest that furosemide may prevent the renal side effects of indomethacin therapy and yet not affect the efficacy of indomethacin in the closure of a PDA.

Original languageEnglish
Pages (from-to)433-437
Number of pages5
JournalThe Journal of Pediatrics
Volume101
Issue number3
DOIs
Publication statusPublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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