Fungal peritonitis in peritoneal dialysis patients: Effect of fluconazole treatment and use of the twin-bag disconnect system

Chih Ming Chen, Mao Wang Ho, Wen Liang Yu, Jen Hsien Wang

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27 Citations (Scopus)

Abstract

Fungal peritonitis is an uncommon but potentially life-threatening complication for patients undergoing continuous ambulatory peritoneal dialysis. This retrospective study evaluated the efficacy of fluconazole in fungal peritonitis treatment and the incidence of fungal peritonitis in different peritoneal dialysis disconnect systems. Fungal peritonitis was caused by Candida species in 67% of episodes. The most common pathogen in this series was Candida parapsilosis (29%), followed by Candida albicans (14%). One patient (5%) died within 1 month after admission for treatment of fungal peritonitis. Only 1 patient (5%) in this series could resume peritoneal dialysis. Treatment with fluconazole alone has an effect comparable to intraperitoneal (IP) amphotericin B alone or IP amphotericin B combined with oral or intravenous fluconazole. The incidence of fungal peritonitis in patients who used the spike, Y-set, and UV antiseptic systems was 5.69, 6.20, and 2.93 times, respectively, as frequent as that of fungal peritonitis in patients who used the twin-bag disconnect system.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Volume37
Issue number2
Publication statusPublished - Apr 2004
Externally publishedYes

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Keywords

  • Dialysis instrumentation
  • Fluconazole
  • Peritoneal dialysis
  • Peritonitis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)

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