Fungal mycelia as the source of chitin and polysaccharides and their applications as skin substitutes

Ching Hua Su, Chi Shu Sun, Shan Wei Juan, Jun-Hung Hu, Wen Ting Ke, Ming Thau Sheu

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

A wovenable skin substitute (Sacchachitin) made from the residue of the fruiting body of Ganoderma tsugae was developed in this study. Chemical analysis revealed that the treated residue was a copolymer of β-1,3-glucan (ca 60%) and N-acetylglucosamine (ca 40%) with a filamental structure of mycelia form, as demonstrated by both optical and scanning electron microscopy. The pulp-like white residue was then woven into thin, porous sheets 7.0 cm in diameter and 0.1-0.2 mm in thickness by filtration and lyophilized for use as a skin substitute. The wound area produced by dissecting rat skin of full thickness was found to almost completely heal on the side covered with Sacchachitin, whereas the control side covered with cotton gauge was around 6.0 cm2 on the 28th day. Furthermore, the wound healing effects of the chitin sheet from crab shell (Beschitin®) and Sacchachitin were not found to be significantly different.

Original languageEnglish
Pages (from-to)1169-1174
Number of pages6
JournalBiomaterials
Volume18
Issue number17
DOIs
Publication statusPublished - Sep 1997

Keywords

  • β-1,3-glucan
  • Fungal mycelia
  • Ganoderma tsugae
  • Poly(N-acetylglucosamine)
  • Skin substitute
  • Wound healing

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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