Functions of DNA methyltransferase 3-like in germ cells and beyond

Hung Fu Liao; Kang Yu Tai; Wendy S.C. Chen; Luca C.W. Cheng; Hong Nerng Ho; Shau Ping Lin

doi:10.1111/boc.201100109

Functions of DNA methyltransferase 3-like in germ cells and beyond

Hung Fu Liao, Kang Yu Tai, Wendy S.C. Chen, Luca C.W. Cheng, Hong Nerng Ho, Shau Ping Lin

Research output: Contribution to journal › Review article

17 Citations (Scopus)

Abstract

DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.

Original language	English
Pages (from-to)	571-587
Number of pages	17
Journal	Biology of the Cell
Volume	104
Issue number	10
DOIs	https://doi.org/10.1111/boc.201100109
Publication status	Published - Oct 1 2012
Externally published	Yes

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Keywords

DNA Methyltransferases
Genomic Imprinting
Histone
PiRNA
Retrotransposons

ASJC Scopus subject areas

Cell Biology

Cite this

Liao, H. F., Tai, K. Y., Chen, W. S. C., Cheng, L. C. W., Ho, H. N., & Lin, S. P. (2012). Functions of DNA methyltransferase 3-like in germ cells and beyond. Biology of the Cell, 104(10), 571-587. https://doi.org/10.1111/boc.201100109

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10.1111/boc.201100109