Functions of DNA methyltransferase 3-like in germ cells and beyond

Hung Fu Liao; Kang Yu Tai; Wendy S.C. Chen; Luca C.W. Cheng; Hong Nerng Ho; Shau Ping Lin

doi:10.1111/boc.201100109

Functions of DNA methyltransferase 3-like in germ cells and beyond

Hung Fu Liao, Kang Yu Tai, Wendy S.C. Chen, Luca C.W. Cheng, Hong Nerng Ho, Shau Ping Lin

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.

Original language	English
Pages (from-to)	571-587
Number of pages	17
Journal	Biology of the Cell
Volume	104
Issue number	10
DOIs	https://doi.org/10.1111/boc.201100109
Publication status	Published - Oct 1 2012
Externally published	Yes

Keywords

DNA Methyltransferases
Genomic Imprinting
Histone
PiRNA
Retrotransposons

ASJC Scopus subject areas

Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/boc.201100109

Cite this

@article{0e7decd13be541dd9af56a1af678316e,

title = "Functions of DNA methyltransferase 3-like in germ cells and beyond",

abstract = "DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.",

keywords = "DNA Methyltransferases, Genomic Imprinting, Histone, PiRNA, Retrotransposons",

author = "Liao, {Hung Fu} and Tai, {Kang Yu} and Chen, {Wendy S.C.} and Cheng, {Luca C.W.} and Ho, {Hong Nerng} and Lin, {Shau Ping}",

year = "2012",

month = oct,

day = "1",

doi = "10.1111/boc.201100109",

language = "English",

volume = "104",

pages = "571--587",

journal = "Biologie Cellulaire",

issn = "0248-4900",

publisher = "Portland Press Ltd.",

number = "10",

}

TY - JOUR

T1 - Functions of DNA methyltransferase 3-like in germ cells and beyond

AU - Liao, Hung Fu

AU - Tai, Kang Yu

AU - Chen, Wendy S.C.

AU - Cheng, Luca C.W.

AU - Ho, Hong Nerng

AU - Lin, Shau Ping

PY - 2012/10/1

Y1 - 2012/10/1

N2 - DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.

AB - DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.

KW - DNA Methyltransferases

KW - Genomic Imprinting

KW - Histone

KW - PiRNA

KW - Retrotransposons

UR - http://www.scopus.com/inward/record.url?scp=84866934046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84866934046&partnerID=8YFLogxK

U2 - 10.1111/boc.201100109

DO - 10.1111/boc.201100109

M3 - Review article

C2 - 22671959

AN - SCOPUS:84866934046

VL - 104

SP - 571

EP - 587

JO - Biologie Cellulaire

JF - Biologie Cellulaire

SN - 0248-4900

IS - 10

ER -

Functions of DNA methyltransferase 3-like in germ cells and beyond

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this