Abstract
DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.
| Original language | English |
|---|---|
| Pages (from-to) | 571-587 |
| Number of pages | 17 |
| Journal | Biology of the Cell |
| Volume | 104 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Oct 1 2012 |
| Externally published | Yes |
Keywords
- DNA Methyltransferases
- Genomic Imprinting
- Histone
- PiRNA
- Retrotransposons
ASJC Scopus subject areas
- Cell Biology
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Cite this
Liao, H. F., Tai, K. Y., Chen, W. S. C., Cheng, L. C. W., Ho, H. N., & Lin, S. P. (2012). Functions of DNA methyltransferase 3-like in germ cells and beyond. Biology of the Cell, 104(10), 571-587. https://doi.org/10.1111/boc.201100109