Functions of DNA methyltransferase 3-like in germ cells and beyond

Hung Fu Liao; Kang Yu Tai; Wendy S.C. Chen; Luca C.W. Cheng; Hong Nerng Ho; Shau Ping Lin

doi:10.1111/boc.201100109

Functions of DNA methyltransferase 3-like in germ cells and beyond

Hung Fu Liao, Kang Yu Tai, Wendy S.C. Chen, Luca C.W. Cheng, Hong Nerng Ho, Shau Ping Lin

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.

Original language	English
Pages (from-to)	571-587
Number of pages	17
Journal	Biology of the Cell
Volume	104
Issue number	10
DOIs	https://doi.org/10.1111/boc.201100109
Publication status	Published - Oct 1 2012
Externally published	Yes

Keywords

DNA Methyltransferases
Genomic Imprinting
Histone
PiRNA
Retrotransposons

ASJC Scopus subject areas

Cell Biology

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abstract = "DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.",

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AU - Liao, Hung Fu

AU - Tai, Kang Yu

AU - Chen, Wendy S.C.

AU - Cheng, Luca C.W.

AU - Ho, Hong Nerng

AU - Lin, Shau Ping

PY - 2012/10/1

Y1 - 2012/10/1

N2 - DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.

AB - DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.

KW - DNA Methyltransferases

KW - Genomic Imprinting

KW - Histone

KW - PiRNA

KW - Retrotransposons

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M3 - Review article

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Functions of DNA methyltransferase 3-like in germ cells and beyond

Abstract

Keywords

ASJC Scopus subject areas

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