Functions of DNA methyltransferase 3-like in germ cells and beyond

Hung Fu Liao, Kang Yu Tai, Wendy S.C. Chen, Luca C.W. Cheng, Hong Nerng Ho, Shau Ping Lin

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.

Original languageEnglish
Pages (from-to)571-587
Number of pages17
JournalBiology of the Cell
Volume104
Issue number10
DOIs
Publication statusPublished - Oct 1 2012
Externally publishedYes

Fingerprint

Methyltransferases
Germ Cells
DNA
Retroelements
Epigenomics
Stem Cell Research
Untranslated RNA
DNA Methylation
Genome

Keywords

  • DNA Methyltransferases
  • Genomic Imprinting
  • Histone
  • PiRNA
  • Retrotransposons

ASJC Scopus subject areas

  • Cell Biology

Cite this

Liao, H. F., Tai, K. Y., Chen, W. S. C., Cheng, L. C. W., Ho, H. N., & Lin, S. P. (2012). Functions of DNA methyltransferase 3-like in germ cells and beyond. Biology of the Cell, 104(10), 571-587. https://doi.org/10.1111/boc.201100109

Functions of DNA methyltransferase 3-like in germ cells and beyond. / Liao, Hung Fu; Tai, Kang Yu; Chen, Wendy S.C.; Cheng, Luca C.W.; Ho, Hong Nerng; Lin, Shau Ping.

In: Biology of the Cell, Vol. 104, No. 10, 01.10.2012, p. 571-587.

Research output: Contribution to journalReview article

Liao, HF, Tai, KY, Chen, WSC, Cheng, LCW, Ho, HN & Lin, SP 2012, 'Functions of DNA methyltransferase 3-like in germ cells and beyond', Biology of the Cell, vol. 104, no. 10, pp. 571-587. https://doi.org/10.1111/boc.201100109
Liao, Hung Fu ; Tai, Kang Yu ; Chen, Wendy S.C. ; Cheng, Luca C.W. ; Ho, Hong Nerng ; Lin, Shau Ping. / Functions of DNA methyltransferase 3-like in germ cells and beyond. In: Biology of the Cell. 2012 ; Vol. 104, No. 10. pp. 571-587.
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