Functions of DNA methyltransferase 3-like in germ cells and beyond

Hung Fu Liao, Kang Yu Tai, Wendy S.C. Chen, Luca C.W. Cheng, Hong Nerng Ho, Shau Ping Lin

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.

Original languageEnglish
Pages (from-to)571-587
Number of pages17
JournalBiology of the Cell
Volume104
Issue number10
DOIs
Publication statusPublished - Oct 1 2012
Externally publishedYes

Keywords

  • DNA Methyltransferases
  • Genomic Imprinting
  • Histone
  • PiRNA
  • Retrotransposons

ASJC Scopus subject areas

  • Cell Biology

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