Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia

Shih Hsiang Liao, Chia Hung Liu, Bishnu Prasad Bastakoti, Norihiro Suzuki, Yung Chang, Yusuke Yamauchi, Feng Huei Lin, Kevin C.W. Wu

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fuid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe3O4) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe3O4@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic feld, the results indicate that Fe3O4@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.

Original languageEnglish
Pages (from-to)3315-3328
Number of pages14
JournalInternational Journal of Nanomedicine
Volume10
DOIs
Publication statusPublished - May 4 2015

Fingerprint

Alginate
Iron oxides
Nanoparticles
Fever
Galactosamine
Coprecipitation
Biocompatibility
Nanostructures
Tumors
Therapeutics
Drug Delivery Systems
Gels
Ligands
Cells
Hepatocellular Carcinoma
Neoplasms
Cell Line
Temperature
ferric oxide
alginic acid

Keywords

  • Alginate
  • Hyperthermia
  • Iron oxide
  • Pre-gel
  • Targeting

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Drug Discovery
  • Organic Chemistry

Cite this

Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia. / Liao, Shih Hsiang; Liu, Chia Hung; Bastakoti, Bishnu Prasad; Suzuki, Norihiro; Chang, Yung; Yamauchi, Yusuke; Lin, Feng Huei; Wu, Kevin C.W.

In: International Journal of Nanomedicine, Vol. 10, 04.05.2015, p. 3315-3328.

Research output: Contribution to journalArticle

Liao, Shih Hsiang ; Liu, Chia Hung ; Bastakoti, Bishnu Prasad ; Suzuki, Norihiro ; Chang, Yung ; Yamauchi, Yusuke ; Lin, Feng Huei ; Wu, Kevin C.W. / Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia. In: International Journal of Nanomedicine. 2015 ; Vol. 10. pp. 3315-3328.
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