Functional role of post-translational modifications of Sp1 in tumorigenesis

Wen Chang Chang, Jan Jong Hung

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Specific protein 1 (Sp1), the first transcription factor to be isolated, regulates the expression of numerous genes involved in cell proliferation, apoptosis, and differentiation. Recent studies found that an increase in Sp1 transcriptional activity is associated with the tumorigenesis. Moreover, post-translational modifications of Sp1, including glycosylation, phosphorylation, acetylation, sumoylation, ubiquitination, and methylation, regulate Sp1 transcriptional activity and modulate target gene expression by affecting its DNA binding activity, transactivation activity, or protein level. In addition, recent studies have investigated several compounds with anti-cancer activity that could inhibit Sp1 transcriptional activity. In this review, we describe the effect of various post-translational modifications on Sp1 transcriptional activity and discuss compounds that inhibit the activity of Sp1.

Original languageEnglish
Article number94
JournalJournal of Biomedical Science
Volume19
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Post Translational Protein Processing
Carcinogenesis
Proteins
Sumoylation
Gene Expression
Glycosylation
Ubiquitination
Acetylation
Phosphorylation
Methylation
Cell proliferation
Transcriptional Activation
Cell Differentiation
Gene expression
Transcription Factors
Cell Proliferation
Apoptosis
Genes
DNA
Neoplasms

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Pharmacology (medical)

Cite this

Functional role of post-translational modifications of Sp1 in tumorigenesis. / Chang, Wen Chang; Hung, Jan Jong.

In: Journal of Biomedical Science, Vol. 19, No. 1, 94, 2012.

Research output: Contribution to journalArticle

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