Functional MRI reveals frequency-dependent responses during deep brain stimulation at the subthalamic nucleus or internal globus pallidus

Hsin-Yi Lai, John Robert Younce, Daniel L. Albaugh, Yu-Chieh Jill Kao, Yen-Yu Shih

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Deep brain stimulation (DBS) represents a widely used therapeutic tool for the symptomatic treatment of movement disorders, most commonly Parkinson's disease (PD). High frequency stimulation at both the subthalamic nucleus (STN) and internal globus pallidus (GPi) has been used with great success for the symptomatic treatment of PD, although the therapeutic mechanisms of action remain elusive. To better understand how DBS at these target sites modulates neural circuitry, the present study used functional blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to map global brain responses to DBS at the STN and GPi of the rat. Robust activation centered in the ipsilateral motor cortex was observed during high frequency stimulation at either target site, with peak responses observed at a stimulation frequency of 100Hz. Of note, frequency tuning curves were generated, demonstrating that cortical activation was maximal at clinically-relevant stimulation frequencies. Divergent responses to stimulation were noted in the contralateral hemisphere, with strong cortical and striatal negative BOLD signal during stimulation of the GPi, but not STN. The frequency-dependence of the observed motor cortex activation at both targets suggests a relationship with the therapeutic effects of STN and GPi DBS, with both DBS targets being functionally connected with motor cortex at therapeutic stimulation frequencies. © 2013.
Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalNeuroImage
Volume84
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Subthalamic Nucleus
Globus Pallidus
Deep Brain Stimulation
Magnetic Resonance Imaging
Motor Cortex
Secondary Parkinson Disease
Therapeutics
Corpus Striatum
Movement Disorders
Therapeutic Uses
Parkinson Disease
Brain

Keywords

  • Deep brain stimulation
  • fMRI
  • Functional connectivity
  • Internal globus pallidus
  • Rat
  • Subthalamic nucleus
  • animal
  • brain depth stimulation
  • connectome
  • electroencephalogram
  • globus pallidus
  • male
  • motor cortex
  • nerve cell network
  • nuclear magnetic resonance imaging
  • physiology
  • procedures
  • rat
  • Sprague Dawley rat
  • subthalamic nucleus
  • Animals
  • Brain Waves
  • Connectome
  • Deep Brain Stimulation
  • Globus Pallidus
  • Magnetic Resonance Imaging
  • Male
  • Motor Cortex
  • Nerve Net
  • Rats
  • Rats, Sprague-Dawley
  • Subthalamic Nucleus

Cite this

Functional MRI reveals frequency-dependent responses during deep brain stimulation at the subthalamic nucleus or internal globus pallidus. / Lai, Hsin-Yi; Younce, John Robert; Albaugh, Daniel L.; Kao, Yu-Chieh Jill; Shih, Yen-Yu.

In: NeuroImage, Vol. 84, 2014, p. 11-18.

Research output: Contribution to journalArticle

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