Abstract
Surgical or traumatic brain injury often leads to loss of cerebral parenchyma but there is as yet no clinically effective strategy for neural regeneration. Collagen glycosaminoglycan (collagen-GAG, CG) scaffolds have previously been used in many tissues invivo but have never been utilized in the brain. Using an animal model, we investigated the effects of the implantation of CG scaffold matrix following surgical brain trauma. Results indicated that implantation of CG scaffold could significantly promote functional recovery following surgical brain trauma. The CG scaffold was found to facilitate proliferation, differentiation and migration of endogenous neural precursor cells (NPCs) both in the intra-matrix zone (IMZ) and lesion boundary zone (LBZ). The tissue concentration of brain-derived neurotrophic factor (BDNF) and glia-derived neurotrophic factor (GDNF) in the cortex demonstrated a sustained increase after implantation of CG scaffold following surgical brain trauma. These results suggest that the utilization of CG scaffolds can be considered as a potential clinical strategy for tissue regeneration and functional recovery after brain injury.
| Original language | English |
|---|---|
| Pages (from-to) | 2067-2075 |
| Number of pages | 9 |
| Journal | Biomaterials |
| Volume | 33 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Mar 2012 |
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Keywords
- Brain
- Cell proliferation
- Collagen-GAG
- Functional recovery
- Neurotrophic factor
- Scaffold
ASJC Scopus subject areas
- Biomaterials
- Bioengineering
- Ceramics and Composites
- Mechanics of Materials
- Biophysics
Cite this
Functional improvement and neurogenesis after collagen-GAG matrix implantation into surgical brain trauma. / Huang, Kuo Feng; Hsu, Wei-Cherng; Chiu, Wen Ta; Wang, Jia Yi.
In: Biomaterials, Vol. 33, No. 7, 03.2012, p. 2067-2075.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Functional improvement and neurogenesis after collagen-GAG matrix implantation into surgical brain trauma
AU - Huang, Kuo Feng
AU - Hsu, Wei-Cherng
AU - Chiu, Wen Ta
AU - Wang, Jia Yi
PY - 2012/3
Y1 - 2012/3
N2 - Surgical or traumatic brain injury often leads to loss of cerebral parenchyma but there is as yet no clinically effective strategy for neural regeneration. Collagen glycosaminoglycan (collagen-GAG, CG) scaffolds have previously been used in many tissues invivo but have never been utilized in the brain. Using an animal model, we investigated the effects of the implantation of CG scaffold matrix following surgical brain trauma. Results indicated that implantation of CG scaffold could significantly promote functional recovery following surgical brain trauma. The CG scaffold was found to facilitate proliferation, differentiation and migration of endogenous neural precursor cells (NPCs) both in the intra-matrix zone (IMZ) and lesion boundary zone (LBZ). The tissue concentration of brain-derived neurotrophic factor (BDNF) and glia-derived neurotrophic factor (GDNF) in the cortex demonstrated a sustained increase after implantation of CG scaffold following surgical brain trauma. These results suggest that the utilization of CG scaffolds can be considered as a potential clinical strategy for tissue regeneration and functional recovery after brain injury.
AB - Surgical or traumatic brain injury often leads to loss of cerebral parenchyma but there is as yet no clinically effective strategy for neural regeneration. Collagen glycosaminoglycan (collagen-GAG, CG) scaffolds have previously been used in many tissues invivo but have never been utilized in the brain. Using an animal model, we investigated the effects of the implantation of CG scaffold matrix following surgical brain trauma. Results indicated that implantation of CG scaffold could significantly promote functional recovery following surgical brain trauma. The CG scaffold was found to facilitate proliferation, differentiation and migration of endogenous neural precursor cells (NPCs) both in the intra-matrix zone (IMZ) and lesion boundary zone (LBZ). The tissue concentration of brain-derived neurotrophic factor (BDNF) and glia-derived neurotrophic factor (GDNF) in the cortex demonstrated a sustained increase after implantation of CG scaffold following surgical brain trauma. These results suggest that the utilization of CG scaffolds can be considered as a potential clinical strategy for tissue regeneration and functional recovery after brain injury.
KW - Brain
KW - Cell proliferation
KW - Collagen-GAG
KW - Functional recovery
KW - Neurotrophic factor
KW - Scaffold
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U2 - 10.1016/j.biomaterials.2011.11.040
DO - 10.1016/j.biomaterials.2011.11.040
M3 - Article
C2 - 22169139
AN - SCOPUS:84855727422
VL - 33
SP - 2067
EP - 2075
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 7
ER -