Functional improvement and neurogenesis after collagen-GAG matrix implantation into surgical brain trauma

Kuo Feng Huang, Wei-Cherng Hsu, Wen Ta Chiu, Jia Yi Wang

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Surgical or traumatic brain injury often leads to loss of cerebral parenchyma but there is as yet no clinically effective strategy for neural regeneration. Collagen glycosaminoglycan (collagen-GAG, CG) scaffolds have previously been used in many tissues invivo but have never been utilized in the brain. Using an animal model, we investigated the effects of the implantation of CG scaffold matrix following surgical brain trauma. Results indicated that implantation of CG scaffold could significantly promote functional recovery following surgical brain trauma. The CG scaffold was found to facilitate proliferation, differentiation and migration of endogenous neural precursor cells (NPCs) both in the intra-matrix zone (IMZ) and lesion boundary zone (LBZ). The tissue concentration of brain-derived neurotrophic factor (BDNF) and glia-derived neurotrophic factor (GDNF) in the cortex demonstrated a sustained increase after implantation of CG scaffold following surgical brain trauma. These results suggest that the utilization of CG scaffolds can be considered as a potential clinical strategy for tissue regeneration and functional recovery after brain injury.

Original languageEnglish
Pages (from-to)2067-2075
Number of pages9
JournalBiomaterials
Volume33
Issue number7
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Neurogenesis
Collagen
Scaffolds (biology)
Brain
Scaffolds
Regeneration
Tissue
Recovery
Tissue regeneration
Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Traumatic Brain Injury
Glycosaminoglycans
Neuroglia
Brain Injuries
Animals
Animal Models

Keywords

  • Brain
  • Cell proliferation
  • Collagen-GAG
  • Functional recovery
  • Neurotrophic factor
  • Scaffold

ASJC Scopus subject areas

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

Functional improvement and neurogenesis after collagen-GAG matrix implantation into surgical brain trauma. / Huang, Kuo Feng; Hsu, Wei-Cherng; Chiu, Wen Ta; Wang, Jia Yi.

In: Biomaterials, Vol. 33, No. 7, 03.2012, p. 2067-2075.

Research output: Contribution to journalArticle

Huang, Kuo Feng ; Hsu, Wei-Cherng ; Chiu, Wen Ta ; Wang, Jia Yi. / Functional improvement and neurogenesis after collagen-GAG matrix implantation into surgical brain trauma. In: Biomaterials. 2012 ; Vol. 33, No. 7. pp. 2067-2075.
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