Functional effects of let-7g expression in colon cancer metastasis

Che Mai Chang, Henry Sung Ching Wong, Chien Yu Huang, Wen Li Hsu, Zhi Feng Maio, Siou Jin Chiu, Yao Ting Tsai, Ben Kuen Chen, Yu Jui Yvonne Wan, Jaw Yuan Wang, Wei Chiao Chang

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1 Citation (Scopus)

Abstract

MicroRNA regulation is crucial for gene expression and cell functions. It has been linked to tumorigenesis, development and metastasis in colorectal cancer (CRC). Recently, the let-7 family has been identified as a tumor suppressor in different types of cancers. However, the function of the let-7 family in CRC metastasis has not been fully investigated. Here, we focused on analyzing the role of let-7g in CRC. The Cancer Genome Atlas (TCGA) genomic datasets of CRC and detailed data from a Taiwanese CRC cohort were applied to study the expression pattern of let-7g. In addition, in vitro as well as in vivo studies have been performed to uncover the effects of let-7g on CRC. We found that the expression of let-7g was significantly lower in CRC specimens. Our results further supported the inhibitory effects of let-7g on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. We report a critical role for let-7g in the pathogenesis of CRC and suggest let-7g as a potential therapeutic target for CRC treatment.

Original languageEnglish
Article number489
JournalCancers
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 1 2019

Keywords

  • Colorectal cancer
  • Let-7g
  • MicroRNA
  • Store-operated calcium (SOC)
  • The cancer genome atlas (TCGA)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Chang, C. M., Wong, H. S. C., Huang, C. Y., Hsu, W. L., Maio, Z. F., Chiu, S. J., Tsai, Y. T., Chen, B. K., Wan, Y. J. Y., Wang, J. Y., & Chang, W. C. (2019). Functional effects of let-7g expression in colon cancer metastasis. Cancers, 11(4), [489]. https://doi.org/10.3390/cancers11040489