Functional characterization of caudal hypoglossal neurons by spectral patterns of neuronal discharges in the rat

C. C.H. Yang, T. B.J. Kuo, S. H.H. Chan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This study evaluated the spectral characteristics of neuronal discharges in the caudal hypoglossal nucleus and their physiological relevance in adult, male Sprague-Dawley rats which were anaesthetized and maintained with pentobarbital sodium. Based on auto-spectral analysis of extracellular single-neuron activity, three spectral patterns were identified in the spontaneous discharges of hypoglossal neurons. Neurons that exhibited a rhythmic pattern manifested a concentrated peak in the auto-spectrogram that corresponded to the mean discharge rate. A majority of hypoglossal neurons displayed the modulated pattern, which was manifested either as scattered power densities (wide-band modulated pattern) or with a peak frequency component that was different from the mean discharge rate (narrow-band modulated pattern). Neurons that exhibited a mixed pattern displayed both rhythmic and modulated spectral patterns. Cross-spectral analysis further revealed that respiratory modulation constituted a major physiological influence on caudal hypoglossal neurons. The respiratory modulated pattern, however, could be converted to a mixed pattern in the presence of a central dipsogen, angiotensin III. The results suggest that the spectral patterns of neuronal discharges in caudal hypoglossal neurons represent manifestations of multiple physiological information, including that regarding respiration and dipsogenesis, which is encoded in these neurons. It was also shown that this information may only be revealed by auto-spectral and cross-spectral analysis of neuronal discharge signals.

Original languageEnglish
Pages (from-to)813-827
Number of pages15
JournalNeuroscience
Volume77
Issue number3
DOIs
Publication statusPublished - Feb 3 1997
Externally publishedYes

Fingerprint

Neurons
Angiotensin III
Pentobarbital
Sprague Dawley Rats
Respiration

Keywords

  • auto-spectral and cross-spectral analysis
  • hypoglossal neuron
  • interchangeable spectral patterns
  • physiological modulation
  • single-neuronal discharge

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Functional characterization of caudal hypoglossal neurons by spectral patterns of neuronal discharges in the rat. / Yang, C. C.H.; Kuo, T. B.J.; Chan, S. H.H.

In: Neuroscience, Vol. 77, No. 3, 03.02.1997, p. 813-827.

Research output: Contribution to journalArticle

@article{a89c6dc11ece45d08c179b1d018f8059,
title = "Functional characterization of caudal hypoglossal neurons by spectral patterns of neuronal discharges in the rat",
abstract = "This study evaluated the spectral characteristics of neuronal discharges in the caudal hypoglossal nucleus and their physiological relevance in adult, male Sprague-Dawley rats which were anaesthetized and maintained with pentobarbital sodium. Based on auto-spectral analysis of extracellular single-neuron activity, three spectral patterns were identified in the spontaneous discharges of hypoglossal neurons. Neurons that exhibited a rhythmic pattern manifested a concentrated peak in the auto-spectrogram that corresponded to the mean discharge rate. A majority of hypoglossal neurons displayed the modulated pattern, which was manifested either as scattered power densities (wide-band modulated pattern) or with a peak frequency component that was different from the mean discharge rate (narrow-band modulated pattern). Neurons that exhibited a mixed pattern displayed both rhythmic and modulated spectral patterns. Cross-spectral analysis further revealed that respiratory modulation constituted a major physiological influence on caudal hypoglossal neurons. The respiratory modulated pattern, however, could be converted to a mixed pattern in the presence of a central dipsogen, angiotensin III. The results suggest that the spectral patterns of neuronal discharges in caudal hypoglossal neurons represent manifestations of multiple physiological information, including that regarding respiration and dipsogenesis, which is encoded in these neurons. It was also shown that this information may only be revealed by auto-spectral and cross-spectral analysis of neuronal discharge signals.",
keywords = "auto-spectral and cross-spectral analysis, hypoglossal neuron, interchangeable spectral patterns, physiological modulation, single-neuronal discharge",
author = "Yang, {C. C.H.} and Kuo, {T. B.J.} and Chan, {S. H.H.}",
year = "1997",
month = "2",
day = "3",
doi = "10.1016/S0306-4522(96)00515-5",
language = "English",
volume = "77",
pages = "813--827",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Functional characterization of caudal hypoglossal neurons by spectral patterns of neuronal discharges in the rat

AU - Yang, C. C.H.

AU - Kuo, T. B.J.

AU - Chan, S. H.H.

PY - 1997/2/3

Y1 - 1997/2/3

N2 - This study evaluated the spectral characteristics of neuronal discharges in the caudal hypoglossal nucleus and their physiological relevance in adult, male Sprague-Dawley rats which were anaesthetized and maintained with pentobarbital sodium. Based on auto-spectral analysis of extracellular single-neuron activity, three spectral patterns were identified in the spontaneous discharges of hypoglossal neurons. Neurons that exhibited a rhythmic pattern manifested a concentrated peak in the auto-spectrogram that corresponded to the mean discharge rate. A majority of hypoglossal neurons displayed the modulated pattern, which was manifested either as scattered power densities (wide-band modulated pattern) or with a peak frequency component that was different from the mean discharge rate (narrow-band modulated pattern). Neurons that exhibited a mixed pattern displayed both rhythmic and modulated spectral patterns. Cross-spectral analysis further revealed that respiratory modulation constituted a major physiological influence on caudal hypoglossal neurons. The respiratory modulated pattern, however, could be converted to a mixed pattern in the presence of a central dipsogen, angiotensin III. The results suggest that the spectral patterns of neuronal discharges in caudal hypoglossal neurons represent manifestations of multiple physiological information, including that regarding respiration and dipsogenesis, which is encoded in these neurons. It was also shown that this information may only be revealed by auto-spectral and cross-spectral analysis of neuronal discharge signals.

AB - This study evaluated the spectral characteristics of neuronal discharges in the caudal hypoglossal nucleus and their physiological relevance in adult, male Sprague-Dawley rats which were anaesthetized and maintained with pentobarbital sodium. Based on auto-spectral analysis of extracellular single-neuron activity, three spectral patterns were identified in the spontaneous discharges of hypoglossal neurons. Neurons that exhibited a rhythmic pattern manifested a concentrated peak in the auto-spectrogram that corresponded to the mean discharge rate. A majority of hypoglossal neurons displayed the modulated pattern, which was manifested either as scattered power densities (wide-band modulated pattern) or with a peak frequency component that was different from the mean discharge rate (narrow-band modulated pattern). Neurons that exhibited a mixed pattern displayed both rhythmic and modulated spectral patterns. Cross-spectral analysis further revealed that respiratory modulation constituted a major physiological influence on caudal hypoglossal neurons. The respiratory modulated pattern, however, could be converted to a mixed pattern in the presence of a central dipsogen, angiotensin III. The results suggest that the spectral patterns of neuronal discharges in caudal hypoglossal neurons represent manifestations of multiple physiological information, including that regarding respiration and dipsogenesis, which is encoded in these neurons. It was also shown that this information may only be revealed by auto-spectral and cross-spectral analysis of neuronal discharge signals.

KW - auto-spectral and cross-spectral analysis

KW - hypoglossal neuron

KW - interchangeable spectral patterns

KW - physiological modulation

KW - single-neuronal discharge

UR - http://www.scopus.com/inward/record.url?scp=0031550613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031550613&partnerID=8YFLogxK

U2 - 10.1016/S0306-4522(96)00515-5

DO - 10.1016/S0306-4522(96)00515-5

M3 - Article

C2 - 9070754

AN - SCOPUS:0031550613

VL - 77

SP - 813

EP - 827

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

IS - 3

ER -