Abstract
This 28-year-old male, a hepatitis B virus (HBV) carrier, received cadaveric renal transplantation and was maintained on cyclosporin A and prednisolone. Jaundice occurred 8 months after the transplantation and he dies 2 weeks later due to hepatic failure. The liver histologic findings were compatible with fibrosing cholestatic hepatitis (FCH), which is caused by HBV and has only been reported in liver allografts of orthotopic liver transplantations. This is the first case of FCH developing in a renal transplant recipient. The report illustrates that (1) is also a unique histologic entity in renal transplantations; (2) FCH might occur in a liver chronically infected by HBV without co-existing hepatitis D virus; and (3) FCH can cause fulminant hepatic failure within one year after transplantation while the patient is still in an immunosuppressed state.
| Original language | English |
|---|---|
| Pages (from-to) | 913-918 |
| Number of pages | 6 |
| Journal | Hepato-Gastroenterology |
| Volume | 42 |
| Issue number | 6 |
| Publication status | Published - 1995 |
| Externally published | Yes |
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Keywords
- Fibrosing cholestatic hepatitis
- Fulminant hepatic failure
- Hepatitis B virus
- Renal transplantation
ASJC Scopus subject areas
- Gastroenterology
Cite this
Fulminant hepatic failure in a renal transplant recipient with positive hepatitis B surface antigens : A case report of fibrosing cholestatic hepatitis. / Hung, Y. B.; Liang, J. T.; Chu, J. S.; Chen, K. M.; Lee, C. S.
In: Hepato-Gastroenterology, Vol. 42, No. 6, 1995, p. 913-918.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fulminant hepatic failure in a renal transplant recipient with positive hepatitis B surface antigens
T2 - A case report of fibrosing cholestatic hepatitis
AU - Hung, Y. B.
AU - Liang, J. T.
AU - Chu, J. S.
AU - Chen, K. M.
AU - Lee, C. S.
PY - 1995
Y1 - 1995
N2 - This 28-year-old male, a hepatitis B virus (HBV) carrier, received cadaveric renal transplantation and was maintained on cyclosporin A and prednisolone. Jaundice occurred 8 months after the transplantation and he dies 2 weeks later due to hepatic failure. The liver histologic findings were compatible with fibrosing cholestatic hepatitis (FCH), which is caused by HBV and has only been reported in liver allografts of orthotopic liver transplantations. This is the first case of FCH developing in a renal transplant recipient. The report illustrates that (1) is also a unique histologic entity in renal transplantations; (2) FCH might occur in a liver chronically infected by HBV without co-existing hepatitis D virus; and (3) FCH can cause fulminant hepatic failure within one year after transplantation while the patient is still in an immunosuppressed state.
AB - This 28-year-old male, a hepatitis B virus (HBV) carrier, received cadaveric renal transplantation and was maintained on cyclosporin A and prednisolone. Jaundice occurred 8 months after the transplantation and he dies 2 weeks later due to hepatic failure. The liver histologic findings were compatible with fibrosing cholestatic hepatitis (FCH), which is caused by HBV and has only been reported in liver allografts of orthotopic liver transplantations. This is the first case of FCH developing in a renal transplant recipient. The report illustrates that (1) is also a unique histologic entity in renal transplantations; (2) FCH might occur in a liver chronically infected by HBV without co-existing hepatitis D virus; and (3) FCH can cause fulminant hepatic failure within one year after transplantation while the patient is still in an immunosuppressed state.
KW - Fibrosing cholestatic hepatitis
KW - Fulminant hepatic failure
KW - Hepatitis B virus
KW - Renal transplantation
UR - http://www.scopus.com/inward/record.url?scp=0029561865&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029561865&partnerID=8YFLogxK
M3 - Article
C2 - 8847045
AN - SCOPUS:0029561865
VL - 42
SP - 913
EP - 918
JO - Acta hepato-splenologica
JF - Acta hepato-splenologica
SN - 0172-6390
IS - 6
ER -