Fucoidan supplementation improves exercise performance and exhibits anti-fatigue action in mice

Yi Ming Chen, Yi Hsin Tsai, Tsung Yu Tsai, Yen Shuo Chiu, Li Wei, Wen Chyuan Chen, Chi Chang Huang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Fucoidan (FCD) is a well-known bioactive constituent of seaweed extract that possess a wide spectrum of activities in biological systems, including anti-cancer, anti-inflammation and modulation of immune systems. However, evidence on the effects of FCD on exercise performance and physical fatigue is limited. Therefore, we investigated the potential beneficial effects of FCD on ergogenic and anti-fatigue functions following physiological challenge. Male ICR mice from three groups (n = 8 per group) were orally administered FCD for 21 days at 0, 310 and 620 mg/kg/day, which were, respectively, designated the vehicle, FCD-1X and FCD-2X groups. The results indicated that the FCD supplementations increased the grip strength (p = 0.0002) and endurance swimming time (p = 0.0195) in a dose-depend manner. FCD treatments also produced dose-dependent decreases in serum levels of lactate (p < 0.0001) and ammonia (p = 0.0025), and also an increase in glucose level (p < 0.0001) after the 15-min swimming test. In addition, FCD supplementation had few subchronic toxic effects. Therefore, we suggest that long-term supplementation with FCD can have a wide spectrum of bioactivities on health promotion, performance improvement and anti-fatigue.

Original languageEnglish
Pages (from-to)239-252
Number of pages14
JournalNutrients
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 31 2015

Fingerprint

fucoidan
Fatigue
exercise
mice
Seaweed
Inbred ICR Mouse
health promotion
Poisons
Hand Strength
dosage
Health Promotion
Ammonia
lactates
immune system
macroalgae
bioactive properties
Immune System
Lactic Acid
ammonia
inflammation

Keywords

  • Brown seaweed extract
  • Exercise performance
  • Forelimb grip strength

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Chen, Y. M., Tsai, Y. H., Tsai, T. Y., Chiu, Y. S., Wei, L., Chen, W. C., & Huang, C. C. (2015). Fucoidan supplementation improves exercise performance and exhibits anti-fatigue action in mice. Nutrients, 7(1), 239-252. https://doi.org/10.3390/nu7010239

Fucoidan supplementation improves exercise performance and exhibits anti-fatigue action in mice. / Chen, Yi Ming; Tsai, Yi Hsin; Tsai, Tsung Yu; Chiu, Yen Shuo; Wei, Li; Chen, Wen Chyuan; Huang, Chi Chang.

In: Nutrients, Vol. 7, No. 1, 31.12.2015, p. 239-252.

Research output: Contribution to journalArticle

Chen, YM, Tsai, YH, Tsai, TY, Chiu, YS, Wei, L, Chen, WC & Huang, CC 2015, 'Fucoidan supplementation improves exercise performance and exhibits anti-fatigue action in mice', Nutrients, vol. 7, no. 1, pp. 239-252. https://doi.org/10.3390/nu7010239
Chen, Yi Ming ; Tsai, Yi Hsin ; Tsai, Tsung Yu ; Chiu, Yen Shuo ; Wei, Li ; Chen, Wen Chyuan ; Huang, Chi Chang. / Fucoidan supplementation improves exercise performance and exhibits anti-fatigue action in mice. In: Nutrients. 2015 ; Vol. 7, No. 1. pp. 239-252.
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