Fucoidan and fucoxanthin attenuate hepatic steatosis and inflammation of nafld through modulation of leptin/adiponectin axis

Ping Hsiao Shih, Sheng Jie Shiue, Chun Nan Chen, Sheng Wei Cheng, Hsin Yi Lin, Li Wei Wu, Ming Shun Wu

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Non-alcoholic fatty liver disease (NAFLD) is the emerging cause of chronic liver disease globally and lack of approved therapies. Here, we investigated the feasibility of combinatorial effects of low molecular weight fucoidan and high stability fucoxanthin (LMF-HSFx) as a therapeutic approach against NAFLD. We evaluated the inhibitory effects of LMF-HSFx or placebo in 42 NAFLD patients for 24 weeks and related mechanism in high fat diet (HFD) mice model and HepaRG™ cell line. We found that LMF-HSFx reduces the relative values of alanine aminotransferase, aspartate aminotransferase, total cholesterol, triglyceride, fasting blood glucose and hemoglobin A1c in NAFLD patients. For lipid metabolism, LMF-HSFx reduces the scores of controlled attenuation parameter (CAP) and increases adiponectin and leptin expression. Interestingly, it reduces liver fibrosis in NAFLD patients, either. The proinflammatory cytokines interleukin (IL)-6 and interferon-γ are reduced in LMF-HSFx group. In HFD mice, LMF-HSFx attenuates hepatic lipotoxicity and modulates adipogenesis. Additionally, LMF-HSFx modulates SIRI-PGC-1 pathway in HepaRG cells under palmitic acid-induced lipotoxicity environment. Here, we describe that LMF-HSFx ameliorated hepatic steatosis, inflammation, fibrosis and insulin resistance in NAFLD patients. LMF-HSFx may modulate leptin-adiponectin axis in adipocytes and hepatocytes, then regulate lipid and glycogen metabolism, decrease insulin resistance and is against NAFLD.

Original languageEnglish
Article number148
JournalMarine Drugs
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 2021

Keywords

  • Adiponectin
  • Lipid metabolism
  • Lipotoxicity
  • Liver fibrosis
  • NAFLD
  • Randomized controlled trial

ASJC Scopus subject areas

  • Drug Discovery

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