From white to beige adipocytes: Therapeutic potential of dietary molecules against obesity and their molecular mechanisms

Siyu Wang, Min Hsiung Pan, Wei Lun Hung, Yen Chen Tung, Chi Tang Ho

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The global incidence of obesity and its complications continue to rise along with a demand for novel therapeutic approaches. In addition to classic brown adipose tissue (BAT), the formation of brown-like adipocytes called beige adipocytes, within white adipose tissue (WAT), has attracted much attention as a therapeutic target due to its inducible features when stimulated, resulting in the dissipation of extra energy as heat. There are various dietary agents that are able to modulate the beige-development process by interacting with critical molecular signaling cascades, leading to the enhancement of thermogenesis. Although challenges still remain regarding the origin of the beige adipocytes, the crosstalk with activation of BAT and induction of the beiging of white fat may provide attractive potential strategies for management of obesity.

Original languageEnglish
Pages (from-to)1263-1279
Number of pages17
JournalFood and Function
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 1 2019

Keywords

  • Adipocytes, Beige/drug effects
  • Adipocytes, White/drug effects
  • Animals
  • Diet
  • Energy Metabolism
  • Humans
  • Obesity/prevention & control

ASJC Scopus subject areas

  • Food Science

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