Free/total prostate specific antigen ratio for prostate cancer detection: A prospective blind study

Chi Rei Yang, Chung Knang Su, Kun Yuan Chiu, Hao Chung Ho, Yen Chuan Ou, Cheng Li Cheng, Huei Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: We conducted this prospective study to evaluate the ability of the percentage of free PSA (% f/t PSA) to improve the specificity of prostate cancer (PC) detection. Materials and Methods: Seven hundred and eighty-five patients with serum PSA levels between 4 and 25 ng/ml underwent sextant biopsies of the prostate. The % f/t PSA was analyzed for the sensitivity, specificity and positive predictive values. Results: The mean % f/t PSA of the 169 patients with PC was 18.0 ± 7.7 and was significantly (p <0.0001) lower than that of the 616 patients who had histologically benign biopsy specimens, with a mean % f/t PSA of 26.6 ± 9.7. Using 30% f/t PSA as the cut-off eliminated 34.4% of the negative biopsies while still detecting 93.4% of the carcinomas. Conclusion: The optimal cut-off value of 30% f/t PSA may be applied as reference using the Cis bio international assay for PC detection.

Original languageEnglish
Pages (from-to)2439-2443
Number of pages5
JournalAnticancer Research
Volume25
Issue number3 C
Publication statusPublished - May 2005
Externally publishedYes

Keywords

  • Free prostate specific antigen
  • Prostate cancer
  • Prostate specific antigen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Yang, C. R., Su, C. K., Chiu, K. Y., Ho, H. C., Ou, Y. C., Cheng, C. L., & Lee, H. (2005). Free/total prostate specific antigen ratio for prostate cancer detection: A prospective blind study. Anticancer Research, 25(3 C), 2439-2443.