Free/total prostate specific antigen ratio for prostate cancer detection

A prospective blind study

Chi Rei Yang, Chung Knang Su, Kun Yuan Chiu, Hao Chung Ho, Yen Chuan Ou, Cheng Li Cheng, Huei Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: We conducted this prospective study to evaluate the ability of the percentage of free PSA (% f/t PSA) to improve the specificity of prostate cancer (PC) detection. Materials and Methods: Seven hundred and eighty-five patients with serum PSA levels between 4 and 25 ng/ml underwent sextant biopsies of the prostate. The % f/t PSA was analyzed for the sensitivity, specificity and positive predictive values. Results: The mean % f/t PSA of the 169 patients with PC was 18.0 ± 7.7 and was significantly (p <0.0001) lower than that of the 616 patients who had histologically benign biopsy specimens, with a mean % f/t PSA of 26.6 ± 9.7. Using 30% f/t PSA as the cut-off eliminated 34.4% of the negative biopsies while still detecting 93.4% of the carcinomas. Conclusion: The optimal cut-off value of 30% f/t PSA may be applied as reference using the Cis bio international assay for PC detection.

Original languageEnglish
Pages (from-to)2439-2443
Number of pages5
JournalAnticancer Research
Volume25
Issue number3 C
Publication statusPublished - May 2005
Externally publishedYes

Fingerprint

Prostate-Specific Antigen
Prostatic Neoplasms
Prospective Studies
Biopsy
Prostate
Carcinoma
Sensitivity and Specificity
Serum

Keywords

  • Free prostate specific antigen
  • Prostate cancer
  • Prostate specific antigen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Yang, C. R., Su, C. K., Chiu, K. Y., Ho, H. C., Ou, Y. C., Cheng, C. L., & Lee, H. (2005). Free/total prostate specific antigen ratio for prostate cancer detection: A prospective blind study. Anticancer Research, 25(3 C), 2439-2443.

Free/total prostate specific antigen ratio for prostate cancer detection : A prospective blind study. / Yang, Chi Rei; Su, Chung Knang; Chiu, Kun Yuan; Ho, Hao Chung; Ou, Yen Chuan; Cheng, Cheng Li; Lee, Huei.

In: Anticancer Research, Vol. 25, No. 3 C, 05.2005, p. 2439-2443.

Research output: Contribution to journalArticle

Yang, CR, Su, CK, Chiu, KY, Ho, HC, Ou, YC, Cheng, CL & Lee, H 2005, 'Free/total prostate specific antigen ratio for prostate cancer detection: A prospective blind study', Anticancer Research, vol. 25, no. 3 C, pp. 2439-2443.
Yang CR, Su CK, Chiu KY, Ho HC, Ou YC, Cheng CL et al. Free/total prostate specific antigen ratio for prostate cancer detection: A prospective blind study. Anticancer Research. 2005 May;25(3 C):2439-2443.
Yang, Chi Rei ; Su, Chung Knang ; Chiu, Kun Yuan ; Ho, Hao Chung ; Ou, Yen Chuan ; Cheng, Cheng Li ; Lee, Huei. / Free/total prostate specific antigen ratio for prostate cancer detection : A prospective blind study. In: Anticancer Research. 2005 ; Vol. 25, No. 3 C. pp. 2439-2443.
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