Foxp1 and Lhx1 coordinate motor neuron migration with axon trajectory choice by gating reelin signalling

Elena Palmesino, David L. Rousso, Tzu Jen Kao, Avihu Klar, Ed Laufer, Osamu Uemura, Hitoshi Okamoto, Bennett G. Novitch, Artur Kania

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Topographic neuronal maps arise as a consequence of axon trajectory choice correlated with the localisation of neuronal soma, but the identity of the pathways coordinating these processes is unknown. We addressed this question in the context of the myotopic map formed by limb muscles innervated by spinal lateral motor column (LMC) motor axons where the Eph receptor signals specifying growth cone trajectory are restricted by Foxp1 and Lhx1 transcription factors. We show that the localisation of LMC neuron cell bodies can be dissociated from axon trajectory choice by either the loss or gain of function of the Reelin signalling pathway. The response of LMC motor neurons to Reelin is gated by Foxp1- and Lhx1-mediated regulation of expression of the critical Reelin signalling intermediate Dab1. Together, these observations point to identical transcription factors that control motor axon guidance and soma migration and reveal the molecular hierarchy of myotopic organisation.

Original languageEnglish
Pages (from-to)41-42
Number of pages2
JournalPLoS Biology
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 2010
Externally publishedYes

Fingerprint

Motor Neurons
motor neurons
axons
Neurons
trajectories
Axons
Trajectories
Carisoprodol
EphA1 Receptor
Transcription Factors
Growth Cones
receptor protein-tyrosine kinase
transcription factors
Extremities
cones (retina)
Muscles
limbs (animal)
neurons
Muscle
Cones

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

Foxp1 and Lhx1 coordinate motor neuron migration with axon trajectory choice by gating reelin signalling. / Palmesino, Elena; Rousso, David L.; Kao, Tzu Jen; Klar, Avihu; Laufer, Ed; Uemura, Osamu; Okamoto, Hitoshi; Novitch, Bennett G.; Kania, Artur.

In: PLoS Biology, Vol. 8, No. 8, 08.2010, p. 41-42.

Research output: Contribution to journalArticle

Palmesino, E, Rousso, DL, Kao, TJ, Klar, A, Laufer, E, Uemura, O, Okamoto, H, Novitch, BG & Kania, A 2010, 'Foxp1 and Lhx1 coordinate motor neuron migration with axon trajectory choice by gating reelin signalling', PLoS Biology, vol. 8, no. 8, pp. 41-42. https://doi.org/10.1371/journal.pbio.1000446
Palmesino, Elena ; Rousso, David L. ; Kao, Tzu Jen ; Klar, Avihu ; Laufer, Ed ; Uemura, Osamu ; Okamoto, Hitoshi ; Novitch, Bennett G. ; Kania, Artur. / Foxp1 and Lhx1 coordinate motor neuron migration with axon trajectory choice by gating reelin signalling. In: PLoS Biology. 2010 ; Vol. 8, No. 8. pp. 41-42.
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