FOXM1 induced by E6 oncoprotein promotes tumor invasion and chemoresistance in HPV-infected lung cancer

Po Ming Chen, Huei Lee

Research output: Contribution to journalArticle

Abstract

Induction of FOXM1 expression by E6 oncoprotein via the MZF1/NKX2-1 axis is responsible for soft-agar growth, invasiveness, and stemness in HPV-positive oral and lung cancer cells. Among patients, the presence of HPV16/18 DNA was positively correlated with NKX2-1 and FOXM1 expression in oral and lung tumors. When oral or lung cancer patients were individually divided into four subgroups by two parameters (HPV and FOXM1), HPV-positive oral or lung cancer patients with high-FOXM1 tumors exhibited the worst overall survival and relapse free survival among the four subgroups of both cancers. Xenograft lung tumor nodules in nude mice injected with HPV-positive oral and or lung cancer stable clones were markedly diminished by FOXM1 inhibitor (thiostrepton). Therefore, we suggest that FOXM1 may potentially represent a therapeutic target in HPV-positive oral or and lung cancer patients with HPV16/18-positive tumors.
Original languageEnglish
JournalCancer Cell & Microenvironment
Publication statusPublished - 2015

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Mouth Neoplasms
Oncogene Proteins
Lung Neoplasms
Neoplasms
Thiostrepton
Lung
Survival
Heterografts
Nude Mice
Agar
Clone Cells
Recurrence
DNA
Growth

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FOXM1 induced by E6 oncoprotein promotes tumor invasion and chemoresistance in HPV-infected lung cancer. / Chen, Po Ming; Lee, Huei.

In: Cancer Cell & Microenvironment, 2015.

Research output: Contribution to journalArticle

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abstract = "Induction of FOXM1 expression by E6 oncoprotein via the MZF1/NKX2-1 axis is responsible for soft-agar growth, invasiveness, and stemness in HPV-positive oral and lung cancer cells. Among patients, the presence of HPV16/18 DNA was positively correlated with NKX2-1 and FOXM1 expression in oral and lung tumors. When oral or lung cancer patients were individually divided into four subgroups by two parameters (HPV and FOXM1), HPV-positive oral or lung cancer patients with high-FOXM1 tumors exhibited the worst overall survival and relapse free survival among the four subgroups of both cancers. Xenograft lung tumor nodules in nude mice injected with HPV-positive oral and or lung cancer stable clones were markedly diminished by FOXM1 inhibitor (thiostrepton). Therefore, we suggest that FOXM1 may potentially represent a therapeutic target in HPV-positive oral or and lung cancer patients with HPV16/18-positive tumors.",
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AB - Induction of FOXM1 expression by E6 oncoprotein via the MZF1/NKX2-1 axis is responsible for soft-agar growth, invasiveness, and stemness in HPV-positive oral and lung cancer cells. Among patients, the presence of HPV16/18 DNA was positively correlated with NKX2-1 and FOXM1 expression in oral and lung tumors. When oral or lung cancer patients were individually divided into four subgroups by two parameters (HPV and FOXM1), HPV-positive oral or lung cancer patients with high-FOXM1 tumors exhibited the worst overall survival and relapse free survival among the four subgroups of both cancers. Xenograft lung tumor nodules in nude mice injected with HPV-positive oral and or lung cancer stable clones were markedly diminished by FOXM1 inhibitor (thiostrepton). Therefore, we suggest that FOXM1 may potentially represent a therapeutic target in HPV-positive oral or and lung cancer patients with HPV16/18-positive tumors.

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