Formulation and release behavior of doxycycline-alginate hydrogel microparticles embedded into pluronic F127 thermogels as a potential new vehicle for doxycycline intradermal sustained delivery

Stefano Giovagnoli, Tsuimin Tsai, Patrick P. Deluca

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The aim of this work was the formulation and characterization of alginate (ALG)-doxycycline (DOX) hydrogel microparticles (MPs) embedded into Pluronic F127 thermogel for DOX intradermal sustained delivery. ALG-DOX MPs were formed by adding a solution of the drug into a 1.5% polymer solution while stirring. The MPs were cross-linked by dispersion into a 1.2% CaCl2 solution. Free MPs were characterized in terms of size, drug content, and release behavior by HPLC and UV-vis. DOX and hydrogel MPs were embedded into PF127, PF127-HPMC, and PF127-Methocel thermogels. The thermogels were characterized in terms of gelling time, morphology, and release behavior. A target release period of 4-7 days was considered optimal. The hydrogel MPs were about 20 μm in size with 90% of the population

Original languageEnglish
Pages (from-to)212-220
Number of pages9
JournalAAPS PharmSciTech
Volume11
Issue number1
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Doxycycline
  • Hydrogel microparticles
  • Sustained release
  • Thermogel

ASJC Scopus subject areas

  • Pharmaceutical Science

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