Formulation and evaluation of lansoprazole niosome

Naresh Ahuja, Vipin Saini, Vijay Kumar Bishnoi, Atul Garg, Monika Hisoria, Joyati Sharma, Kunal Nepali

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The niosomes formulation has got various advantages over conventional dosage forms; these stay in the blood for longer time then conventional and can thus greatly improve the therapeutic effect of drug. In many diseases (e. g. cancer) a considerable therapeutic advantage could be gained if drugs were delivered in selective and controlled manner to their target sites. The noisome are prepared by reverse phase evaporation method using a homogenizers. Non-ionic surfactant based vesicles used as vesicles for drug formulation have been found to reduce the systemic toxicity of many drugs. Lansoprazole was selected as candidate drug, it is antacid and antiulcer agents. Niosomes are characterized for its size rang, entrapment efficiency and in-vitro release of drug. For release study the phosphate buffer saline pH 8. 6 was used and the samples were assayed by UV.

Original languageEnglish
Pages (from-to)561-563
Number of pages3
JournalRasayan Journal of Chemistry
Volume1
Issue number3
Publication statusPublished - Jan 1 2008
Externally publishedYes

Keywords

  • Controlled release
  • Lansoprazole
  • Niosomes
  • Target site

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Energy(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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