Formulation and evaluation of diclofenac sodium gel by using natural polymer

Naresh Ahuja, Vipin Saini, Vijay Kumar Bishnoi, Atul Garg, Monika Hisoria, Joyati Sharma, Kunal Nepali

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A major problem being faced in ocular therapeutic is the attainment of an optimal concentration at the site of action1. The bioavailability of diclofenac sodium in the form of eye drop is very low and when the drug is administered in the form of ophthalmic suspension it lead to irritation due to particle size. So in the present study diclofenac sodium gels were developed with the aim of promoting the prolong release of drug using natural polymer. Diclofenac sodium gels were sterilized and assessed for various parameters like clarity, viscosity, pH, extrudability and sterility. In -vitro drug release determined using dialysis membrane in phosphate buffer pH 7. 4. Ocular irritation studies were performed on albino rabbits.

Original languageEnglish
Pages (from-to)564-566
Number of pages3
JournalRasayan Journal of Chemistry
Volume1
Issue number3
Publication statusPublished - Jan 1 2008
Externally publishedYes

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Keywords

  • Gel
  • Natural polymer
  • Ophthalmic preparation
  • Prolong release

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Energy(all)

Cite this

Ahuja, N., Saini, V., Bishnoi, V. K., Garg, A., Hisoria, M., Sharma, J., & Nepali, K. (2008). Formulation and evaluation of diclofenac sodium gel by using natural polymer. Rasayan Journal of Chemistry, 1(3), 564-566.