Formation of organosilica nanoparticles with dual functional groups and simultaneous payload entrapment

Ya Ling Su, Chien Yu Lin, Shih Jiuan Chiu, Teh Min Hu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A mixed organosilane system for simultaneous formation of organosilica nanoparticles has been systematically studied for loading of various compounds with a wide range of log P values. The molecule-entrapping system was understood by investigating the effects of adjusting various experimental parameters on particle formation and molecule entrapment. Particularly, rhodamine 6 G (R6G) loaded colloidal particles were prepared and characterised in detail. The results show that whereas most molecules had entrapment efficiency (EE%) in the range of 20–80%, R6G exhibited near 100% efficiency. Moreover, the colloidal system can be tuned to incorporate R6G with the extent of entrapment spanning at least 2 orders of magnitude (i.e. from 0.04 to 4 mg) and a maximum EE% of 98%. In conclusion, the study demonstrates the promise of the proposed mixed organosilane system in forming colloidal particles containing multiple functional groups with selective loading of highly hydrophobic molecules.

Original languageEnglish
Pages (from-to)381-391
Number of pages11
JournalJournal of Microencapsulation
Volume35
Issue number4
DOIs
Publication statusPublished - May 19 2018

Fingerprint

Rhodamines
entrapment
payloads
Nanoparticles
Functional groups
rhodamine
nanoparticles
Molecules
molecules
adjusting

Keywords

  • nanoparticle
  • nanoprecipitation
  • organosilane
  • Silica
  • silsesquioxane

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

Cite this

Formation of organosilica nanoparticles with dual functional groups and simultaneous payload entrapment. / Su, Ya Ling; Lin, Chien Yu; Chiu, Shih Jiuan; Hu, Teh Min.

In: Journal of Microencapsulation, Vol. 35, No. 4, 19.05.2018, p. 381-391.

Research output: Contribution to journalArticle

@article{f2e89ab7434d47c5ba4de86d606a67dd,
title = "Formation of organosilica nanoparticles with dual functional groups and simultaneous payload entrapment",
abstract = "A mixed organosilane system for simultaneous formation of organosilica nanoparticles has been systematically studied for loading of various compounds with a wide range of log P values. The molecule-entrapping system was understood by investigating the effects of adjusting various experimental parameters on particle formation and molecule entrapment. Particularly, rhodamine 6 G (R6G) loaded colloidal particles were prepared and characterised in detail. The results show that whereas most molecules had entrapment efficiency (EE{\%}) in the range of 20–80{\%}, R6G exhibited near 100{\%} efficiency. Moreover, the colloidal system can be tuned to incorporate R6G with the extent of entrapment spanning at least 2 orders of magnitude (i.e. from 0.04 to 4 mg) and a maximum EE{\%} of 98{\%}. In conclusion, the study demonstrates the promise of the proposed mixed organosilane system in forming colloidal particles containing multiple functional groups with selective loading of highly hydrophobic molecules.",
keywords = "nanoparticle, nanoprecipitation, organosilane, Silica, silsesquioxane, nanoparticle, nanoprecipitation, organosilane, Silica, silsesquioxane",
author = "Su, {Ya Ling} and Lin, {Chien Yu} and Chiu, {Shih Jiuan} and Hu, {Teh Min}",
year = "2018",
month = "5",
day = "19",
doi = "10.1080/02652048.2018.1508314",
language = "English",
volume = "35",
pages = "381--391",
journal = "Journal of Microencapsulation",
issn = "0265-2048",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Formation of organosilica nanoparticles with dual functional groups and simultaneous payload entrapment

AU - Su, Ya Ling

AU - Lin, Chien Yu

AU - Chiu, Shih Jiuan

AU - Hu, Teh Min

PY - 2018/5/19

Y1 - 2018/5/19

N2 - A mixed organosilane system for simultaneous formation of organosilica nanoparticles has been systematically studied for loading of various compounds with a wide range of log P values. The molecule-entrapping system was understood by investigating the effects of adjusting various experimental parameters on particle formation and molecule entrapment. Particularly, rhodamine 6 G (R6G) loaded colloidal particles were prepared and characterised in detail. The results show that whereas most molecules had entrapment efficiency (EE%) in the range of 20–80%, R6G exhibited near 100% efficiency. Moreover, the colloidal system can be tuned to incorporate R6G with the extent of entrapment spanning at least 2 orders of magnitude (i.e. from 0.04 to 4 mg) and a maximum EE% of 98%. In conclusion, the study demonstrates the promise of the proposed mixed organosilane system in forming colloidal particles containing multiple functional groups with selective loading of highly hydrophobic molecules.

AB - A mixed organosilane system for simultaneous formation of organosilica nanoparticles has been systematically studied for loading of various compounds with a wide range of log P values. The molecule-entrapping system was understood by investigating the effects of adjusting various experimental parameters on particle formation and molecule entrapment. Particularly, rhodamine 6 G (R6G) loaded colloidal particles were prepared and characterised in detail. The results show that whereas most molecules had entrapment efficiency (EE%) in the range of 20–80%, R6G exhibited near 100% efficiency. Moreover, the colloidal system can be tuned to incorporate R6G with the extent of entrapment spanning at least 2 orders of magnitude (i.e. from 0.04 to 4 mg) and a maximum EE% of 98%. In conclusion, the study demonstrates the promise of the proposed mixed organosilane system in forming colloidal particles containing multiple functional groups with selective loading of highly hydrophobic molecules.

KW - nanoparticle

KW - nanoprecipitation

KW - organosilane

KW - Silica

KW - silsesquioxane

KW - nanoparticle

KW - nanoprecipitation

KW - organosilane

KW - Silica

KW - silsesquioxane

UR - http://www.scopus.com/inward/record.url?scp=85053318973&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053318973&partnerID=8YFLogxK

U2 - 10.1080/02652048.2018.1508314

DO - 10.1080/02652048.2018.1508314

M3 - Article

AN - SCOPUS:85053318973

VL - 35

SP - 381

EP - 391

JO - Journal of Microencapsulation

JF - Journal of Microencapsulation

SN - 0265-2048

IS - 4

ER -