Flow cytometric DNA analysis of colorectal carcinoid

Jhy Young Cheng, Jih Chang Lin, Dah Shyong Yu, Wei Hwa Lee, Ching Liang Meng

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12 Citations (Scopus)

Abstract

We analyzed the patterns of DNA ploidy in 31 colorectal carcinoid tumors from paraffin-embedded tissues by DNA flow cytometry and the relationship of the patterns of DNA ploidy to prognosis. Diploid DNA was found in 78% (24 of 31) of carcinoids and tetraploid in 6% (2 of 31). Five (16%) carcinoids were DNA aneuploid, and four of the patients with aneuploidy showing a near-hypertriploid pattern died during the first 5 years of follow-up. The association of aneuploidy with stage, size, and invasion of tumor was significant. However, our data indicated that DNA aneuploidy of a near-hypertriploid pattern was the most precise and reliable parameter for predicting the prognosis of colorectal carcinoid tumors.

Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalAmerican Journal of Surgery
Volume168
Issue number1
DOIs
Publication statusPublished - 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Surgery

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