Flexible Optogenetic Transducer Device for Remote Neuron Modulation Using Highly Upconversion-Efficient Dendrite-Like Gold Inverse Opaline Structure

Chao Yi Chu, Pu Wei Wu, Jung Chih Chen, Nien Ti Tsou, You Yi Lin, Yu Chun Lo, Ssu Ju Li, Ching Wen Chang, Bo Wei Chen, Chia Lin Tsai, You Yin Chen, Ta Chung Liu, San Yuan Chen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A remote optogenetic device for analyzing freely moving animals has attracted extensive attention in optogenetic engineering. In particular, for peripheral nerve regions, a flexible device is needed to endure the continuous bending movements of these areas. Here, a remote optogenetic optical transducer device made from a gold inverse opaline skeleton grown with a dendrite-like gold nanostructure (D-GIOF) and chemically grafted with upconversion nanoparticles (UCNPs) is developed. This implantable D-GIOF-based transducer device can achieve synergistic interaction of the photonic crystal effect and localized surface plasmon resonance, resulting in considerable UCNP conversion efficiency with a negligible thermal effect under low-intensity 980 nm near-infrared (NIR) light excitation. Furthermore, the D-GIOF-based transducer device exhibits remarkable emission power retention (≈100%) under different bending states, indicating its potential for realizing peripheral nerve stimulation. Finally, the D-GIOF-based transducer device successfully stimulates neuronal activities of the sciatic nerve in mice. This study demonstrates the potential of the implantable device to promote remote NIR stimulation for modulation of neural activity in peripheral nerve regions and provides proof of concept for its in vivo application in optogenetic engineering.

Original languageEnglish
Article number2101310
JournalAdvanced healthcare materials
Volume11
Issue number11
DOIs
Publication statusAccepted/In press - 2022

Keywords

  • flexible NIR transducer devices
  • in situ electrochemicals
  • inverse opal
  • localized surface plasmon resonance (LSPR)
  • optogenetics
  • photonic crystal (PC)
  • remote neural modulation

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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