Fish oil reduces hepatic injury by maintaining normal intestinal permeability and microbiota in chronic ethanol-fed rats

Jiun Rong Chen, Ya Ling Chen, Hsiang Chi Peng, Yu An Lu, Hsiao Li Chuang, Hsiao Yun Chang, Hsiao Yun Wang, Yu Ju Su, Suh Ching Yang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aim of this study was to investigate the ameliorative effects of fish oil on hepatic injury in ethanol-fed rats based on the intestinal permeability and microbiota. Rats were assigned to 6 groups and fed either a control diet or an ethanol diet such as C (control), CF25 (control with 25% fish oil), CF57 (control with 57% fish oil), E (ethanol), EF25 (ethanol with 25% fish oil), and EF57 (ethanol with 57% fish oil) groups. Rats were sacrificed at the end of 8 weeks. Plasma aspartate aminotransferase (AST) and aminotransferase (ALT) activities, hepatic cytokines, and plasma endotoxin levels were significantly higher in the E group. In addition, hepatic histopathological analysis scores in the E group were significantly elevated. Rats in the E group also showed increased intestinal permeability and decreased numbers of fecal Bifidobacterium. However, plasma AST and ALT activities and hepatic cytokine levels were significantly lower in the EF25 and EF57 groups. Histological changes and intestinal permeability were also improved in the EF25 and EF57 groups. The fecal Escherichia coli numbers were significantly lower, but fecal Bifidobacterium numbers were significantly higher in the EF25 and EF57 groups.

Original languageEnglish
Article number4694726
JournalGastroenterology Research and Practice
Volume2016
DOIs
Publication statusPublished - 2016

Fingerprint

Fish Oils
Permeability
Ethanol
Liver
Wounds and Injuries
Bifidobacterium
Aspartate Aminotransferases
Cytokines
Diet
Transaminases
Endotoxins
Gastrointestinal Microbiome
Escherichia coli

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Fish oil reduces hepatic injury by maintaining normal intestinal permeability and microbiota in chronic ethanol-fed rats. / Chen, Jiun Rong; Chen, Ya Ling; Peng, Hsiang Chi; Lu, Yu An; Chuang, Hsiao Li; Chang, Hsiao Yun; Wang, Hsiao Yun; Su, Yu Ju; Yang, Suh Ching.

In: Gastroenterology Research and Practice, Vol. 2016, 4694726, 2016.

Research output: Contribution to journalArticle

@article{4549bb0c7e134e298d8e87b2d4f93170,
title = "Fish oil reduces hepatic injury by maintaining normal intestinal permeability and microbiota in chronic ethanol-fed rats",
abstract = "The aim of this study was to investigate the ameliorative effects of fish oil on hepatic injury in ethanol-fed rats based on the intestinal permeability and microbiota. Rats were assigned to 6 groups and fed either a control diet or an ethanol diet such as C (control), CF25 (control with 25{\%} fish oil), CF57 (control with 57{\%} fish oil), E (ethanol), EF25 (ethanol with 25{\%} fish oil), and EF57 (ethanol with 57{\%} fish oil) groups. Rats were sacrificed at the end of 8 weeks. Plasma aspartate aminotransferase (AST) and aminotransferase (ALT) activities, hepatic cytokines, and plasma endotoxin levels were significantly higher in the E group. In addition, hepatic histopathological analysis scores in the E group were significantly elevated. Rats in the E group also showed increased intestinal permeability and decreased numbers of fecal Bifidobacterium. However, plasma AST and ALT activities and hepatic cytokine levels were significantly lower in the EF25 and EF57 groups. Histological changes and intestinal permeability were also improved in the EF25 and EF57 groups. The fecal Escherichia coli numbers were significantly lower, but fecal Bifidobacterium numbers were significantly higher in the EF25 and EF57 groups.",
author = "Chen, {Jiun Rong} and Chen, {Ya Ling} and Peng, {Hsiang Chi} and Lu, {Yu An} and Chuang, {Hsiao Li} and Chang, {Hsiao Yun} and Wang, {Hsiao Yun} and Su, {Yu Ju} and Yang, {Suh Ching}",
year = "2016",
doi = "10.1155/2016/4694726",
language = "English",
volume = "2016",
journal = "Gastroenterology Research and Practice",
issn = "1687-6121",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Fish oil reduces hepatic injury by maintaining normal intestinal permeability and microbiota in chronic ethanol-fed rats

AU - Chen, Jiun Rong

AU - Chen, Ya Ling

AU - Peng, Hsiang Chi

AU - Lu, Yu An

AU - Chuang, Hsiao Li

AU - Chang, Hsiao Yun

AU - Wang, Hsiao Yun

AU - Su, Yu Ju

AU - Yang, Suh Ching

PY - 2016

Y1 - 2016

N2 - The aim of this study was to investigate the ameliorative effects of fish oil on hepatic injury in ethanol-fed rats based on the intestinal permeability and microbiota. Rats were assigned to 6 groups and fed either a control diet or an ethanol diet such as C (control), CF25 (control with 25% fish oil), CF57 (control with 57% fish oil), E (ethanol), EF25 (ethanol with 25% fish oil), and EF57 (ethanol with 57% fish oil) groups. Rats were sacrificed at the end of 8 weeks. Plasma aspartate aminotransferase (AST) and aminotransferase (ALT) activities, hepatic cytokines, and plasma endotoxin levels were significantly higher in the E group. In addition, hepatic histopathological analysis scores in the E group were significantly elevated. Rats in the E group also showed increased intestinal permeability and decreased numbers of fecal Bifidobacterium. However, plasma AST and ALT activities and hepatic cytokine levels were significantly lower in the EF25 and EF57 groups. Histological changes and intestinal permeability were also improved in the EF25 and EF57 groups. The fecal Escherichia coli numbers were significantly lower, but fecal Bifidobacterium numbers were significantly higher in the EF25 and EF57 groups.

AB - The aim of this study was to investigate the ameliorative effects of fish oil on hepatic injury in ethanol-fed rats based on the intestinal permeability and microbiota. Rats were assigned to 6 groups and fed either a control diet or an ethanol diet such as C (control), CF25 (control with 25% fish oil), CF57 (control with 57% fish oil), E (ethanol), EF25 (ethanol with 25% fish oil), and EF57 (ethanol with 57% fish oil) groups. Rats were sacrificed at the end of 8 weeks. Plasma aspartate aminotransferase (AST) and aminotransferase (ALT) activities, hepatic cytokines, and plasma endotoxin levels were significantly higher in the E group. In addition, hepatic histopathological analysis scores in the E group were significantly elevated. Rats in the E group also showed increased intestinal permeability and decreased numbers of fecal Bifidobacterium. However, plasma AST and ALT activities and hepatic cytokine levels were significantly lower in the EF25 and EF57 groups. Histological changes and intestinal permeability were also improved in the EF25 and EF57 groups. The fecal Escherichia coli numbers were significantly lower, but fecal Bifidobacterium numbers were significantly higher in the EF25 and EF57 groups.

UR - http://www.scopus.com/inward/record.url?scp=84971222261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971222261&partnerID=8YFLogxK

U2 - 10.1155/2016/4694726

DO - 10.1155/2016/4694726

M3 - Article

AN - SCOPUS:84971222261

VL - 2016

JO - Gastroenterology Research and Practice

JF - Gastroenterology Research and Practice

SN - 1687-6121

M1 - 4694726

ER -